Species-barrier on the cross-species oral transmission of bovine AA          amyloidosis in mice

Iwaide, Susumu; Ujike, Naoki; Kobayashi, Kyoko; Sassa, Yukiko; Murakami, Tomoaki

doi:10.1292/jvms.20-0713

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…In prion diseases, prion proteins absorbed and phagocytosed by PP are thought to reach the spleen through mesenteric lymph nodes [ 16 ]. We also previously demonstrated that AA administered in mouse PP migrated to other lymphoid tissues, indicating that amyloid absorbed in the gastrointestinal tract may be transferred through the lymphatic system [ 17 ]. In this study, the PP, which is rich in immune cells [ 18 ] may be more likely to transport the AEF via the lymphatic system than the stomach wall, leading to the spread of amyloid deposits.…”

Section: Discussionmentioning

confidence: 99%

Local administration of amyloid enhancing factor initiates <i>in situ</i> amyloid A deposition followed by systemic lesions in mice

et al. 2023

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Amyloid A (AA) amyloidosis is experimentally transmissible in some animal species, such as mice and chickens. While the spleen is important as the initial deposition site in the transmission of AA amyloidosis, it is not essential for establishing the transmission, and its role is not precisely understood. In this study, to clarify why the spleen is the first site of deposition in transmissible AA amyloidosis, we administered amyloid enhancing factor, which is AA fibrils extracted from AA amyloidosis affected mouse to local organs (liver, spleen, kidney, stomach wall, and Peyer’s patches), to tail vein and into peritoneum; then compared the amyloid distribution. Interestingly, initial amyloid deposition was observed at the administration site in each administered organ, not just the spleen. Furthermore, the amount of amyloid deposition in intra-organ administration groups was larger than that of the intravenous or intraperitoneal administration groups. This study indicates that locally exposed AEF initiates in situ amyloid deposition, from which amyloid deposition spreads throughout the body.

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Section: Discussionmentioning

confidence: 99%

Local administration of amyloid enhancing factor initiates <i>in situ</i> amyloid A deposition followed by systemic lesions in mice

et al. 2023

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AA amyloidosis in vertebrates: epidemiology, pathology and molecular aspects

Moccia,

Tucciarone,

Garutti

et al. 2024

Amyloid

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Photocatalytic Inactivation of Viruses and Prions: Multilevel Approach with Other Disinfectants

Onodera

Sugiura

Haritani

et al. 2022

Applied Microbiology

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Ag, Cu, Zn, Ti, and Au nanoparticles show enhanced photocatalytic properties. Efficient indoor disinfection strategies are imperative to manage the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Virucidal agents, such as ethanol, sodium hypochlorite, 222-nm UV light, and electrolyzed water inactivate SARS-CoV-2 in indoor environments. Tungsten trioxide (WO3) photocatalyst and visible light disinfect abiotic surfaces against SARS-CoV-2. The titanium dioxide (TiO2)/UV system inactivates SARS-CoV-2 in aerosols and on deliberately contaminated TiO2-coated glass slide surfaces in photocatalytic chambers, wherein 405-nm UV light treatment for 20 min sterilizes the environment and generates reactive oxygen species (ROS) that inactivate the virus by targeting S and envelope proteins and viral RNA. Mesoscopic calcium bicarbonate solution (CAC-717) inactivates pathogens, such as prions, influenza virus, SARS-CoV-2, and noroviruses, in fluids; it presumably acts similarly on human and animal skin. The molecular complexity of cementitious materials promotes the photocatalysis of microorganisms. In combination, the two methods can reduce the pathogen load in the environment. As photocatalysts and CAC-717 are potent disinfectants for prions, disinfectants against prionoids could be developed by combining photocatalysis, gas plasma methodology, and CAC-717 treatment, especially for surgical devices and instruments.

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Species-barrier on the cross-species oral transmission of bovine AA amyloidosis in mice

Cited by 3 publications

References 36 publications

Local administration of amyloid enhancing factor initiates <i>in situ</i> amyloid A deposition followed by systemic lesions in mice

Local administration of amyloid enhancing factor initiates <i>in situ</i> amyloid A deposition followed by systemic lesions in mice

AA amyloidosis in vertebrates: epidemiology, pathology and molecular aspects

Photocatalytic Inactivation of Viruses and Prions: Multilevel Approach with Other Disinfectants

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