species and their complicated relationships with human health

Kahler, Charlene M.

doi:10.1071/ma21024

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…During this entrapped state, the interaction with Streptococcus mitis but not Moraxella catarralis, triggered invasive disease via degradation of the encasing mucins. These findings illustrate that whilst the results of in vitro assessments of growth inhibition are important, great caution should be exercised in extrapolating these findings to what happens in vivo [21].…”

Section: Discussionmentioning

confidence: 86%

Neisseria mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae

Abdellati

Laumen

González

et al. 2022

Sci

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Antibiotic-sparing treatments are required to prevent the further emergence of antimicrobial resistance in Neisseria gonorrhoeae. Commensal Neisseria species have previously been found to inhibit the growth of pathogenic Neisseria species. For example, a previous study found that three out of five historical isolates of Neisseria mucosa could inhibit the growth of N. gonorrhoeae. In this study, we used agar overlay assays to assess if 24 circulating and historical isolates of Neisseria mucosa could inhibit the growth of 28 circulating and historical isolates of N. gonorrhoeae. Although pitting around each colony of N. mucosa created an optical illusion of decreased growth of N. gonorrhoeae, we found no evidence of inhibition (n = 24). In contrast, positive controls of Streptococcus pneumoniae and Escherichia coli demonstrated a strong inhibitory effect against the growth of N. gonorrhoeae.

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Section: Discussionmentioning

confidence: 86%

Neisseria mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae

Abdellati

Laumen

González

et al. 2022

Sci

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“…Alternatively, the genera Neisseria , Streptococcus , Fusobacterium , Faecalibacterium , Corynebacterium , and Staphylococcus were comparatively less abundant in COVID patients, suggesting that their reduced abundance may indicate COVID-19 infection. Among them, Neisseria contains two pathogens, Neisseria gonorrhoeae and Neisseria meningitides, which are associated with the meningococcal disease [ 73 ]. In another study, Streptococcus and Fusobacterium are often highly abundant in the oral cavity [ 74 ], and Fusobacterium is also highly associated with periodontal disease [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications

Kibria,

Ali,

Yaseen

et al. 2024

Pharmaceuticals

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SARS-CoV-2 infections, commonly referred to as COVID-19, remain a critical risk to both human life and global economies. Particularly, COVID-19 patients with weak immunity may suffer from different complications due to the bacterial co-infections/super-infections/secondary infections. Therefore, different variants of alternative antibacterial therapeutic agents are required to inhibit those infection-causing drug-resistant pathogenic bacteria. This study attempted to explore these bacterial pathogens and their inhibitors by using integrated statistical and bioinformatics approaches. By analyzing bacterial 16S rRNA sequence profiles, at first, we detected five bacterial genera and taxa (Bacteroides, Parabacteroides, Prevotella Clostridium, Atopobium, and Peptostreptococcus) based on differentially abundant bacteria between SARS-CoV-2 infection and control samples that are significantly enriched in 23 metabolic pathways. A total of 183 bacterial genes were found in the enriched pathways. Then, the top-ranked 10 bacterial genes (accB, ftsB, glyQ, hldD, lpxC, lptD, mlaA, ppsA, ppc, and tamB) were selected as the pathogenic bacterial key genes (bKGs) by their protein–protein interaction (PPI) network analysis. Then, we detected bKG-guided top-ranked eight drug molecules (Bemcentinib, Ledipasvir, Velpatasvir, Tirilazad, Acetyldigitoxin, Entreatinib, Digitoxin, and Elbasvir) by molecular docking. Finally, the binding stability of the top-ranked three drug molecules (Bemcentinib, Ledipasvir, and Velpatasvir) against three receptors (hldD, mlaA, and lptD) was investigated by computing their binding free energies with molecular dynamic (MD) simulation-based MM-PBSA techniques, respectively, and was found to be stable. Therefore, the findings of this study could be useful resources for developing a proper treatment plan against bacterial co-/super-/secondary-infection in SARS-CoV-2 infections.

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“… 66 The Neisseria family includes Neisseria meningitides and Neisseria gonorrhea , responsible for meningitis and gonorrhea. 67 In contrast, Campylobacter causes bacterial diarrhea, 68 which cannot be ignored. In COVID-19 patients, intestinal microbiomes are confirmed using the metagenomic sequencing analysis of fecal samples.…”

Section: Covid-19 Shows Lung Fungal Dysbiosismentioning

confidence: 99%

“…The 16s RNA analysis of feces samples of 20 hospitalized children with acute viral gastroenteritis (AGE) revealed an increased Campylobacteriaceae, Methylobacteriaceae , Neisseria family, Enterobacteriaceae, and Sphingomonas family than the control group . The Neisseria family includes Neisseria meningitides and Neisseria gonorrhea , responsible for meningitis and gonorrhea . In contrast, Campylobacter causes bacterial diarrhea, which cannot be ignored.…”

Section: Covid-19 Shows Lung Fungal Dysbiosismentioning

confidence: 99%

Association of SARS-CoV-2 and Polypharmacy with Gut–Lung Axis: From Pathogenesis to Treatment

et al. 2022

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SARS-CoV-2 is a novel infectious contagion leading to COVID-19 disease. The virus has affected the lives of millions of people across the globe with a high mortality rate. It predominantly affects the lung (respiratory system), but it also affects other organs, including the cardiovascular, psychological, and gastrointestinal (GIT) systems. Moreover, elderly and comorbid patients with compromised organ functioning and pre-existing polypharmacy have worsened COVID-19-associated complications. Microbiota (MB) of the lung plays an important role in developing COVID-19. The extent of damage mainly depends on the predominance of opportunistic pathogens and, inversely, with the predominance of advantageous commensals. Changes in the gut MB are associated with a bidirectional shift in the interaction among the gut with a number of vital human organs, which leads to severe disease symptoms. This review focuses on dysbiosis in the gut–lung axis, COVID-19-induced worsening of comorbidities, and the influence of polypharmacy on MB.

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species and their complicated relationships with human health

Cited by 4 publications

References 37 publications

Neisseria mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae

Neisseria mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae

Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications

Association of SARS-CoV-2 and Polypharmacy with Gut–Lung Axis: From Pathogenesis to Treatment

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