Species and Regional Variations in the Effectiveness of Antivenom against the in Vitro Neurotoxicity of Death Adder (Acanthophis) Venoms

Vintage venoms: Proteomic and pharmacological stability of snake venoms stored for up to eight decades

“…It is also important that vintage venom collections be viewed as bioresources themselves and not merely as historical artefacts -they may represent the last opportunity to discover the potential wonder drugs hidden within the venoms of endangered species of snakes. values in minutes) induced by 10 μg doses of Acanthophis venoms in the chick biventer cervicis nerve-muscle preparation in this study and previous studies [37,38]. …”

Anti-snake venom activities of extracts and fractions from callus cultures ofSapindus saponaria

“…Among other factors that may affect the composition of venoms are geographical location, the animals' health status, age, type of prey, etc. (Fry et al, 2001).…”

232. Death Adder Envenoming Causes Neurotoxicity not Reversed by Antivenom - Australian Snakebite Project (ASP-16)

“…These three concentrations were below those of any of the patients that developed neurotoxicity, indicating that a threshold blood concentration may need to be reached before neurotoxicity occurs. There was one patient with a high death adder venom concentration in their blood sample without any evidence of envenoming, indicating possible inter-person variability in susceptibility to venom effects and/or inter-snake variability in venom toxin composition [10,39] Some possible limitations of the study include the method of selection of cases for examination which in some patients was based upon prior knowledge of the syndrome of death adder envenoming. This may mean that some cases of death adder bite may have been missed and may be the reason for the much higher incidence of neurotoxicity in our study compared to previous studies.…”