Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals

Lompré, Anne‐Marie; Mercadier, Jean-Jacques; Wisnewsky, C; Bouveret, P.; Pantaloni, Colette; d’Albis, Anne; Schwartz, Ketty

doi:10.1016/0012-1606(81)90396-1

Cited by 352 publications

(188 citation statements)

References 20 publications

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“…First, several studies reported that the contractile state of the pressure-overload heart remained unchanged in dogs and pigs, in both of which the pressure-overload was gradually applied in a similar manner as in our study (CARABELLO et al, 1981;WISENBAUGH et al, 1983). Secondly, a shift in myosin enzyme in the above animals did not seem to occur or was not of physiological significance (LoMPRE et al, 1981;WISENBAUGH et al, 1983). Thirdly, recent studies found no alteration in ventricular function when the gain in the left ventricular mass to body weight ratio was from 25 to 65 % of that of the control (CARABELLO et al, 1981;PFEFFER et al, 1976;SASAYAMA et al, 1976; T. NAKAMURA, T. KIMURA, S. ARAI, M. MOTOMIYA, and N. SUZUKI WISENBAUGH et al, 1983).…”

Section: Discussionsupporting

confidence: 62%

Left ventricular function of concentric hypertrophied heart after chronic pressure overload as studied in the isolated canine heart preparation.

et al. 1984

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The function of the pressure-overload left ventricle was studied in relation to the chamber geometry of the isolated canine heart. The occurrence of concentric hypertrophy was confirmed in dogs with aortic constriction 40 weeks after operation. The effect of the concentric hypertrophy on left ventricular function was then studied in five pressure-overload dogs. The end-diastolic pressure of the preparation was preset at 20 mmHg. In the pressure-overload ventricle, the end-diastolic volume was smaller by 47% (p<0.01) and the peak systolic pressure was higher by 24% (p<0.01) than the control at isovolumic beats. Ejection pressure was controlled by our afterload controlling system at various levels and kept constant during the ejection phase. When ejection pressure was the same, the difference in stroke volume between the experimental and control groups was not significant. In the pressure-overload ventricle, the slope (the reciprocal is Emax) of the regression line of the end-systolic volume on ejection pressure decreased (p<0.01) to 0.095 ml/mmHg by 47% from 0.186 ml/mmHg in the control. The volume-axis intercept (Vd) of the line was reduced to 55 % of the control. A decrease in the regression line slope was in linear proportion to the degree of concentric hypertrophy, namely, to the change in chamber geometry. These results indicated that: (1) Despite reduction of the end-diastolic volume, the concentric hypertrophied ventricle showed no reduction in stroke volume at the same level of ejection pressure, because of its improved capability to generate pressure. (2) Ema$ was dependent on ventricular geometry.

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Section: Discussionsupporting

confidence: 62%

Left ventricular function of concentric hypertrophied heart after chronic pressure overload as studied in the isolated canine heart preparation.

et al. 1984

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“…1). As the animal ages, the αMHC level (~40% of total MHCs pool) becomes suppressed again, and βMHC becomes the major isoform [15,16]. In domestic rabbits, the αMHC begins to rise just before birth, as in rats, and reaches levels almost equal to those of βMHC (50:50 α:β ratio) at the age of around two weeks of the animal.…”

Section: Structural Organization and Developmental Regulation Of Myosmentioning

confidence: 99%

“…With the exception of rabbit, the developmental expression of MHC isoforms in other larger species has not been studied. Nonetheless, it is well established that the ventricular myosin composition is characteristic of a given mammalian species during adulthood [15,17]. The fast-contracting hearts of rodents, such as the mouse, rat, and hamster express αMHC predominantly, whereas the slowcontracting hearts of guinea pigs, domestic rabbits, and pigs express mostly βMHC.…”

Section: Structural Organization and Developmental Regulation Of Myosmentioning

confidence: 99%

“…Proteolytic fragment S1, corresponding to myosin head domain and two other proteolytic fragments, S2 and LMM (light meromyosins) corresponding to alpha-helical rod domain are shown. (C) Schematic representation of the developmental regulation of rat and rabbit heart myosin isoforms during fetal, adult and old age of the animal [15,16,154]. Increased activity of PARP1 in physiologic and pathologic hypertrophy.…”

Section: Future Directionsmentioning

confidence: 99%

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Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure

Gupta

2007

Journal of Molecular and Cellular Cardiology

186

173

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“…Although the a-MHC gene is constitutively expressed in the atrium during all stages of development, it is transcriptionally activated in the ventricle a t birth, replacing the 6-MHC transcript as the major transcript in this compartment during embryonic and fetal development (Lyons et al, 1990;Lompre et al, 1981Lompre et al, , 1984Ng et al, 1991). Therefore, it was of interest to investigate the embryonic pattern of p-MHC gene expression in the Pm.…”

Section: Developmental Analyses Of the Murinementioning

confidence: 99%

Murine pulmonary myocardium: Developmental analysis of cardiac gene expression

Jones

Sánchez

Robbins

1994

Developmental Dynamics

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Using ventricle-and atrial-specific riboprobes, we determined that the pulmonary myocardium exhibits an atrial pattern of cardiac-specific gene expression. Additionally, the developmental pattern of expression was studied using a riboprobe specific to the a-cardiac myosin heavy chain (a-MHC) gene transcript. We find that a-MHC gene expression is first detectable in the lung between 13.9-14.3 days post-coitum. Extension of the a-MHC specific hybridization signal into the pulmonary venous bed progresses through the neonatal period. The data are consistent with the hypothesis that the extension of a-MHC gene expression into the lung occurs via the migration of atrial myoblasts into the vein during atrial septation and remodeling of the sinus venosus and pulmonary venous trunk.

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Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals

Cited by 352 publications

References 20 publications

Left ventricular function of concentric hypertrophied heart after chronic pressure overload as studied in the isolated canine heart preparation.

Left ventricular function of concentric hypertrophied heart after chronic pressure overload as studied in the isolated canine heart preparation.

Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure

Murine pulmonary myocardium: Developmental analysis of cardiac gene expression

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