Speciation of arsenic – A review of phenylarsenicals and related arsenic metabolites

Liu, Qingqing; Lu, Xiufen; Peng, Hanyong; Popowich, Aleksandra; Tao, Jeffrey; Uppal, Jagdeesh S.; Yan, Xiaowen; Boe, Dana; Le, X. Chris

doi:10.1016/j.trac.2017.10.006

Cited by 52 publications

(34 citation statements)

References 86 publications

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“…Studies have shown that the sulfhydryl group of the protein (i.e., cysteine) is the major binding site for As(III), while the intermediate metabolites of arsenic such as MMA III and DMA III have high affinity with the cysteine residues of proteins and can be combined with various proteins. These proteins including hemoglobin, metallothionein, thioredoxin peroxidase, glutathione reductase, and glycopeptide peroxidase (Mizumura et al, 2010; Shen et al, 2013; Chen et al, 2015; Liu Q et al, 2018). Metallothionein, a metal-binding protein having cysteine residues and high metal content, was founded in living organisms (Ziller et al, 2017; Scheller et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Liu

Han

et al. 2019

Front. Pharmacol.

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High arsenic residues make Cordyceps sinensis a concern in China. Arsenic toxicity is related to its species. Many studies have evaluated the toxicity of total arsenic, but few have studied its species. In this study, the species of arsenic in C. sinensis and its potential health risk were investigated. SEC-HPLC-ICP-MS was used to analysis of arsenic in C. sinensis and unknown arsenic (uAs) was discovered. Additionally, arsenic in C. sinensis was mainly found in alkali-soluble proteins. The trend of arsenic transformation indicated that unknown arsenic in C. sinensis may be converted into free inorganic arsenic, which enhanced toxicity. The result of risk assessment indicated that there were potential health risks of uAs. Hereon, we proposed recommendations for the use of C. sinensis and regulatory recommendations for arsenic standards. This study contributed to the toxicity reveal, safety evaluation, and risk assessment of arsenic in C. sinensis.

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Section: Discussionmentioning

confidence: 99%

“…The toxicity of arsenic is closely related to its species (Liu Q et al, 2018), different species have different toxicities. Combined with its chemical forms and toxicological characteristics, arsenic is mainly divided into inorganic arsenic (iAs) and organic arsenic (oAs).…”

Section: Introductionmentioning

confidence: 99%

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Liu

Han

et al. 2019

Front. Pharmacol.

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“…In several cases, the MS-MS approach for metal speciation is sufficient, guarantees exceptional sensitivity, and is well-suited for quantitative analysis. At least two independent approaches have been described by Liu et al ( 2018 ) for speciation determination and quantitation of arsenic and its metabolites employing MS-MS.…”

Section: Esi-ms-ms For Metal Speciationmentioning

confidence: 99%

Recent Approaches for Chemical Speciation and Analysis by Electrospray Ionization (ESI) Mass Spectrometry

2021

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In recent years, the chemical speciation of several species has been increasingly monitored and investigated, employing electrospray ionization mass spectrometry (ESI-MS). This soft ionization technique gently desolvates weak metal–ligand complexes, taking them in the high vacuum sectors of mass spectrometric instrumentation. It is, thus, possible to collect information on their structure, energetics, and fragmentation pathways. For this reason, this technique is frequently chosen in a synergistic approach to investigate competitive ligand exchange-adsorption otherwise analyzed by cathodic stripping voltammetry (CLE-ACSV). ESI-MS analyses require a careful experimental design as measurement may face instrumental artifacts such as ESI adduct formation, fragmentation, and sometimes reduction reactions. Furthermore, ESI source differences of ionization efficiencies among the detected species can be misleading. In this mini-review are collected and critically reported the most recent approaches adopted to mitigate or eliminate these limitations and to show the potential of this analytical technique.

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“…They could promote the growth of poultry and controlling diseases, and ROX was widely used as a feed additive in the livestock breeding industry. However, the excessive use of benzene‐containing arsenicals leads to arsenic residues in the organism, which will affect human health [3], and phenylarsenicals using as feed additives have been forbidden in many countries recently. According to the Announcement No.…”

Section: Introductionmentioning

confidence: 99%

Ti (IV) modified vinyl phosphate magnetic nanoparticles for simultaneous preconcentration of multiple arsenic species from chicken samples followed by HPLC‐ICP‐MS analysis

Chen

et al. 2021

Electrophoresis

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Ti (IV)‐modified vinyl phosphate magnetic nanoparticles (Fe3O4@SiO2@KH570‐PO4‐Ti (IV)) was prepared for simultaneous extraction of multiple arsenic species, followed by high performance liquid chromatography (HPLC)– inductively coupled plasma mass spectrometry (ICP‐MS) analysis. Inorganic arsenic (iAs), dimethyl arsenic acid (DMA), monomethyl arsenic acid (MMA), p‐amino phenyl arsenic acid (p‐ASA), 4‐hdroxyphenylarsenic acid (4‐OH), phenyl arsenic acid (PAA), and 3‐nitro‐4‐hydroxyphenylarsenic acid (ROX) were investigated as interest analytes. It was found that they were quantitatively adsorbed on Fe3O4@SiO2@KH570‐PO4‐Ti (IV) at pH 5, and desorbed completely with 0.1 mol/L sodium hydroxide solution. Enrichment factor of 100‐fold was obtained by consuming 100 mL sample solution. Under the optimal conditions, the method combining MSPE with HPLC‐ICP‐MS presented a linear range of 1–5000 ng/L for seven arsenic species. The limits of detection were 0.39, 0.60, 0.23, 1.85, 0.54, 0.48, and 0.84 ng/L for DMA, MMA, p‐ASA, iAs, 4‐OH, PAA, ROX, with the relative standard deviations (c = 10 ng/L, n = 7) of 3.6, 3.9, 5.5, 12.4, 6.1, 5.8, 5.0, respectively. The accuracy of the method was validated by analyzing BCR 627 Tuna fish. The application potential of the method was further evaluated by chicken muscle and liver samples. No target arsenic species were detected in these samples, and good recoveries (80.6–123%) were obtained for the spiked samples at low, medium, and high concentration levels.

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Speciation of arsenic – A review of phenylarsenicals and related arsenic metabolites

Cited by 52 publications

References 86 publications

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Recent Approaches for Chemical Speciation and Analysis by Electrospray Ionization (ESI) Mass Spectrometry

Ti (IV) modified vinyl phosphate magnetic nanoparticles for simultaneous preconcentration of multiple arsenic species from chicken samples followed by HPLC‐ICP‐MS analysis

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