Speciation and toxicity of rhenium salts, organometallics and coordination complexes

Haase, Allison A.; Bauer, Elisabeth B.; Kühn, Fritz E.; Crans, Debbie C.

doi:10.1016/j.ccr.2019.05.012

Cited by 34 publications

(13 citation statements)

References 169 publications

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“…However, according to Knopf et al (2017), the use of different cell lines may result in inconsistencies in some observed biological properties of complexes [ 93 ]. Furthermore, the review by Haase et al (2019), emphasized that ligands may also play a significant role in the cytotoxicity of Re(I) tricarbonyl complexes [ 94 ]. A comparative Table 3 illustrates the active concentrations of the Re(I) tricarbonyl complexes to that of cisplatin (see Figure 4 ) as the reference active anticancer drug.…”

Section: Biological Studiesmentioning

confidence: 99%

Nanoparticles Functionalised with Re(I) Tricarbonyl Complexes for Cancer Theranostics

Mkhatshwa

Moremi

Makgopa

et al. 2021

IJMS

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Globally, cancer is the second (to cardiovascular diseases) leading cause of death. Regardless of various efforts (i.e., finance, research, and workforce) to advance novel cancer theranostics (diagnosis and therapy), there have been few successful attempts towards ongoing clinical treatment options as a result of the complications posed by cancerous tumors. In recent years, the application of magnetic nanomedicine as theranostic devices has garnered enormous attention in cancer treatment research. Magnetic nanoparticles (MNPs) are capable of tuning the magnetic field in their environment, which positively impacts theranostic applications in nanomedicine significantly. MNPs are utilized as contrasting agents for cancer diagnosis, molecular imaging, hyperfusion region visualization, and T cell-based radiotherapy because of their interesting features of small size, high reactive surface area, target ability to cells, and functionalization capability. Radiolabelling of NPs is a powerful diagnostic approach in nuclear medicine imaging and therapy. The use of luminescent radioactive rhenium(I), 188/186Re, tricarbonyl complexes functionalised with magnetite Fe3O4 NPs in nanomedicine has improved the diagnosis and therapy of cancer tumors. This is because the combination of Re(I) with MNPs can improve low distribution and cell penetration into deeper tissues.

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Section: Biological Studiesmentioning

confidence: 99%

Nanoparticles Functionalised with Re(I) Tricarbonyl Complexes for Cancer Theranostics

Mkhatshwa

Moremi

Makgopa

et al. 2021

IJMS

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“…Both isotopes are potential candidates for medical applications. 187 Re is a beta emitter that possesses a long-decay half-life but is proposed to be safe for medical use owing to its relatively weak emission of radiation [ 83 , 84 , 85 , 86 , 87 , 88 ]. It has been evaluated as an anticancer drug candidate in clinical trials previously in the form of organic-metal complexes [ 89 , 90 , 91 , 92 , 93 ].…”

Section: Rhenium(i) Tricarbonyl Complexes: General Overviewmentioning

confidence: 99%

Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

Liew

Zulkefeli

et al. 2020

Molecules

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Photodynamic therapy (PDT) is emerging as a significant complementary or alternative approach for cancer treatment. PDT drugs act as photosensitisers, which upon using appropriate wavelength light and in the presence of molecular oxygen, can lead to cell death. Herein, we reviewed the general characteristics of the different generation of photosensitisers. We also outlined the emergence of rhenium (Re) and more specifically, Re(I) tricarbonyl complexes as a new generation of metal-based photosensitisers for photodynamic therapy that are of great interest in multidisciplinary research. The photophysical properties and structures of Re(I) complexes discussed in this review are summarised to determine basic features and similarities among the structures that are important for their phototoxic activity and future investigations. We further examined the in vitro and in vivo efficacies of the Re(I) complexes that have been synthesised for anticancer purposes. We also discussed Re(I) complexes in conjunction with the advancement of two-photon PDT, drug combination study, nanomedicine, and photothermal therapy to overcome the limitation of such complexes, which generally absorb short wavelengths.

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“…In oxic waters, Re VII is the stable oxidation state which undergo hydrolysis to the relatively unreactive perrhenate ion, Re VII O4over an extended pH range (Hasse et al 2019;Kim and Boulègue 2009;Darab and Smith 1996;Colton 1963). Oceanic dissolved Re exhibits quite conservative behavior with a concentration of about 40 pM (Anbar et al 1992;Colodner et al 1993a;Miller et al 2011;Singh et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Rhenium distribution and behaviour in the salinity gradient of a highly stratified estuary and pristine riverine waters

Bura-Nakić

Knežević

Mandić

et al. 2021

Preprint

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The abundance and distribution of dissolved Re (DRe) has been determined in the freshwater part of the Krka River (Croatia), draining the karstic carbonate landscape, as well as in the salinity gradient of its highly stratified estuary. Due to low DRe concentration, the batch procedure consisting of pre-concentration step using an anion exchange resin (Dovex) and analysis of DRe in 8 M HNO 3 eluate using a high resolution inductively coupled plasma mass spectrometry (HR ICP-MS) was adopted. Due to the potential inconsistent recoveries, ranging from 60% to 87%, the quantification was performed by using the isotope dilution (ID) technique. The DRe concentration in the Krka River basically increased in the downstream direction, with the 6.2 pM at the spring site, reaching 11.9 pM before the estuarine region. The weathering of the surrounding carbonate lithology is assumed as the source of natural Re. The two specific anomalies were registered: a strong increase in DRe concentration due to the anthropogenic input near the town of Knin (27.5 pM) and a decrease at downstream site caused by the subterranean input of freshwater of the Zrmanja River leading to relatively low DRe concentration (8.5 pM). In the estuarine segment, a near-conservative behavior of DRe was found in the salinity gradient of the upper surface layer, with the DRe concentration ranging from 18 to 38 pM. An anthropogenic supply was suggested within the estuarine segment close to the urban area causing a small positive deviation from the conservative line. In the bottom seawater layer, a minor decrease of DRe concentration in the most upstream estuarine regions was evidenced, implying a potential weak scavenging of Re.

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Speciation and toxicity of rhenium salts, organometallics and coordination complexes

Cited by 34 publications

References 169 publications

Nanoparticles Functionalised with Re(I) Tricarbonyl Complexes for Cancer Theranostics

Nanoparticles Functionalised with Re(I) Tricarbonyl Complexes for Cancer Theranostics

Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

Rhenium distribution and behaviour in the salinity gradient of a highly stratified estuary and pristine riverine waters

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