Speciation and Reactivity of Mono- and Binuclear Ni Intermediates in Aminoquinoline-Directed C–H Arylation and Benzylation
Emily L. Nolan,
Isaac M. Blythe,
Fengrui Qu
et al.
Abstract:This paper describes detailed organometallic studies of the aminoquinoline-directed Ni-catalyzed C−H functionalization of 2,3,4,5-tetrafluoro-N-(quinolin-8-yl)benzamide with diaryliodonium reagents. A combination of 19 F NMR spectroscopy and X-ray crystallography is used to track and characterize diamagnetic and paramagnetic intermediates throughout this transformation. These provide key insights into both the cyclometalation and oxidative functionalization steps of the catalytic cycle. The reaction conditions… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.