Specialized pro-resolving lipid mediators and resolution of viral diseases

Ferri, Giulia; Mucci, Matteo; Mattoscio, Domenico; Recchiuti, Antonio

doi:10.1016/j.prostaglandins.2023.106762

Cited by 4 publications

(1 citation statement)

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“…Adoptive transfer of alveolar macrophages from young into old mice reduced lung damage following influenza infection [ 124 ]. Another mediator of resolution of inflammation are specialised pro-resolving lipid mediators (SPMs), which are produced by macrophages, and which reduced inflammation and damage during viral and bacterial lung infections [ 125 ]. These SPMs were reduced in homeostasis and following zymosan challenge in aged mice, which led to increased neutrophil influx and delayed resolution of inflammation [ 126 ].…”

Section: Disease Effects Of Respiratory Viral Infectionsmentioning

confidence: 99%

Diverging patterns in innate immunity against respiratory viruses during a lifetime: lessons from the young and the old

Smits,

Jochems

2024

Eur Respir Rev

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Respiratory viral infections frequently lead to severe respiratory disease, particularly in vulnerable populations such as young children, individuals with chronic lung conditions and older adults, resulting in hospitalisation and, in some cases, fatalities. The innate immune system plays a crucial role in monitoring for, and initiating responses to, viruses, maintaining a state of preparedness through the constant expression of antimicrobial defence molecules. Throughout the course of infection, innate immunity remains actively involved, contributing to viral clearance and damage control, with pivotal contributions from airway epithelial cells and resident and newly recruited immune cells. In instances where viral infections persist or are not effectively eliminated, innate immune components prominently contribute to the resulting pathophysiological consequences. Even though both young children and older adults are susceptible to severe respiratory disease caused by various respiratory viruses, the underlying mechanisms may differ significantly. Children face the challenge of developing and maturing their immunity, while older adults contend with issues such as immune senescence and inflammaging. This review aims to compare the innate immune responses in respiratory viral infections across both age groups, identifying common central hubs that could serve as promising targets for innovative therapeutic and preventive strategies, despite the apparent differences in underlying mechanisms.

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Section: Disease Effects Of Respiratory Viral Infectionsmentioning

confidence: 99%