Special Significance of Non-Drosophila Insects in Aging

Guo, Siyuan; Wang, Xianhui; Kang, Le

doi:10.3389/fcell.2020.576571

Cited by 11 publications

(11 citation statements)

References 159 publications

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“…The IR is well-known to be implicated—either directly or by crosstalk with other major hormones such as juvenile hormone (JH) and ecdysteroids (especially 20-hydroxyecdysone, 20E)—in post-embryonic development [ 84 , 85 ], nutrition-based phenotypic plasticity and body size control [ 86 , 87 ], reproduction and diapause [ 55 ], and circadian rhythmicity and behaviors [ 88 , 89 , 90 ]. The IR is also indispensable in insect photoperiodism, lifespan, and aging due to its relation to metabolism and growth [ 25 , 91 , 92 , 93 ]. Overall, studies have indicated that the IR is indispensable in insect growth [ 94 ], development and reproduction [ 95 , 96 ], polymorphism [ 24 ], lifespan [ 97 ], and oviposition [ 98 ].…”

Section: Functions Of the Irmentioning

confidence: 99%

“…In insects, current evidence points to the roles of the IR in regulating development, reproduction, lifespan, caste differentiation, and wing polyphenism [ 24 , 25 , 26 ]. To our knowledge, neonicotinoid insecticides (e.g., imidacloprid) are selective agonists of the nicotinic acetylcholine receptor (nAChR) that have been widely used to control various insects [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides

Zhang

Zhu

et al. 2022

IJMS

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The insulin receptor (IR) is a transmembrane protein that is activated by ligands in insulin signaling pathways. The IR has been considered as a novel therapeutic target for clinical intervention, considering the overexpression of its protein and A-isoform in multiple cancers, Alzheimer’s disease, and Type 2 diabetes mellitus in humans. Meanwhile, it may also serve as a potential target in pest management due to its multiple physiological influences in insects. In this review, we provide an overview of the structural and molecular biology of the IR, functions of IRs in humans and insects, physiological and nonpeptide small molecule modulators of the IR, and the regulating mechanisms of the IR. Xenobiotic compounds and the corresponding insecticidal chemicals functioning on the IR are also discussed. This review is expected to provide useful information for a better understanding of human IR-related diseases, as well as to facilitate the development of novel small-molecule activators and inhibitors of the IR for use as medicines or pesticides.

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Section: Functions Of the Irmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides

Zhang

Zhu

et al. 2022

IJMS

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“…Although work in fruit flies and other lab-adapted insect species has uncovered many mechanisms that contribute to immunosenescence (Sciambra & Chtarbanova, 2021), aging studies in non-model systems will be incredibly important to our understanding of the interaction between infection and aging (Guo et al, 2020).…”

Section: Host Factors That Influence Survival Of Infectionmentioning

confidence: 99%

Host condition and pathogen identity influence bacterial infection survival in the common eastern firefly, Photinus pyralis

Lower

Gilani

Tuffy

et al. 2022

Ecological Entomology

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1. The degree to which host, pathogen, and environmental characteristics determine fitness outcomes in response to infection across the tree of life is a key question in ecoimmunology. Because infection experiments require large sample sizes and careful controls, studies have generally been limited to lab-adapted organisms.2. Photinus pyralis is a charismatic firefly that is abundant during its annual summer emergence in the Eastern United States. Here, we assess the importance of host condition, pathogen identity and dose, and pre-infection environment on survival outcomes in response to bacterial infection in wild-caught adult male P. pyralis.3. Although survival after sterile saline injection was not statistically different from survival of uninjected controls, survival kinetics support sterile saline injection as the most appropriate control. 4. Serratia marcescens and Providencia rettgeri infections increased mortality, especially at high doses. In contrast to fruit fly studies, Providencia sneebia, Pseudomonas aeruginosa, and Enterococcus faecalis infections did not. Infection with higher doses of P. rettgeri had an increased risk of death for fireflies caught later in the season than those captured earlier, but seasonality did not significantly interact with dose to impact mortality with any of the other bacterial species.5. These results highlight the importance of considering host, pathogen, and environmental factors when investigating infection outcomes in wild-caught, non-model systems. The differences in survival between fireflies and fruit flies emphasise that further studies in a broad array of organisms are needed to explore the diversity of infection responses across the tree of life.

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“…Due to the complexity of studying aging in humans, a number of model organisms have been used to unravel molecular mechanisms associated with aging: Drosophila melanogaster [ 7 ] and other insects [ 8 ], Caenorhabditis elegans [ 9 ], Mus musculus [ 10 ] and also mammalian cell lines [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence

Magalhães

Almeida

Pereira

et al. 2022

IJMS

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Aging is a complex process which leads to progressive loss of fitness/capability/ability, increasing susceptibility to disease and, ultimately, death. Regardless of the organism, there are some features common to aging, namely, the loss of proteostasis and cell senescence. Mammalian cell lines have been used as models to study the aging process, in particular, cell senescence. Thus, the aim of this study was to characterize the senescence-associated metabolic profile of a long-term culture of human fibroblasts using Fourier Transform Infrared and Nuclear Magnetic Resonance spectroscopy. We sub-cultivated fibroblasts from a newborn donor from passage 4 to passage 17 and the results showed deep changes in the spectroscopic profile of cells over time. Late passage cells were characterized by a decrease in the length of fatty acid chains, triglycerides and cholesterol and an increase in lipid unsaturation. We also found an increase in the content of intermolecular β-sheets, possibly indicating an increase in protein aggregation levels in cells of later passages. Metabolic profiling by NMR showed increased levels of extracellular lactate, phosphocholine and glycine in cells at later passages. This study suggests that spectroscopy approaches can be successfully used to study changes concomitant with cell senescence and validate the use of human fibroblasts as a model to monitor the aging process.

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Special Significance of Non-Drosophila Insects in Aging

Cited by 11 publications

References 159 publications

The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides

The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides

Host condition and pathogen identity influence bacterial infection survival in the common eastern firefly, Photinus pyralis

The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence

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