Special Section on Cytochrome P450 Enzymes in Toxicology and as Drug Targets—Editorial

Abstract

The special section of "Cytochrome P450 enzymes in toxicology and as drug targets" in the June 2024 issue of Drug Metabolism and Disposition (DMD) is contributed by Dr. Klarissa D. Jackson, the recipient of the 2023 Richard Okita Early Career Award in Drug Metabolism and Disposition (Okita Award, Fig. 1), and her mentors, trainees, and colleagues. Dr. Klarissa D. Jackson earned her Ph.D. degree in pharmacology from Vanderbilt University School of Medicine in the laboratory of Dr. Jason Morrow and Dr. L. Jackson Roberts. Her dissertation research investigated the formation and metabolism of chemically reactive cyclopentenone prostaglandins and isoprostanes under settings of oxidative stress. Dr. Jackson completed her postdoctoral training in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy under the mentorship of Dr. Allan Rettie and Dr. Sidney Nelson. As a postdoctoral fellow, she studied the role of cytochrome P450 (P450)-mediated metabolic activation in the mechanisms of hepatotoxicity associated with the tyrosine kinase inhibitor lapatinib.