Special Issue “Sporothrix and Sporotrichosis 2.0”

Mora-Montes, Héctor M.

doi:10.3390/jof8080821

Cited by 9 publications

(15 citation statements)

References 33 publications

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“…in the host cutaneous tissue. This is considered an implantation mycosis that can occur through an animal or environmental transmission route [ 4 , 5 , 6 , 7 ]. Sporothrix spp.…”

Section: Introductionmentioning

confidence: 99%

Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

Thomson

González

Blank³

et al. 2023

JoF

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Sporotrichosis is an implantation mycosis with subcutaneo-lymphatic or, more rarely, a viscerally disseminated affection; it can be acquired through traumatic percutaneous inoculation of the fungus present in soil or plant matter, or by feline scratching. Among the causative agents, Sporothrix brasiliensis is considered the most virulent species with a high prevalence in Brazil and recently in Argentina. Objective: Describe a S. brasiliensis outbreak in domestic and feral cats detected in the Magallanes region of southern Chile. Materials and Methods: Between the months of July and September 2022, three cats presented with suppurative subcutaneous lesions located mainly on the head and thoracic limbs. The cytology revealed the presence of yeasts with morphological characteristics suggestive of Sporothrix spp. The histopathology confirmed pyogranulomatous subcutaneous lesions associated with the presence of the same yeasts. The fungal culture followed by the partial gene sequence and analysis of the ITS region confirmed the diagnosis of the S. brasiliensis as the causative agent. The cats were treated with itraconazole associated in one case with potassium iodide. The evolution of the patients was favorable in all cases. Conclusions: An outbreak caused by S. brasiliensis was detected in domestic and feral felines in austral Chile. The correct identification of this fungus and antifungigram is essential for treatment decisions and for designing dissemination control and prevention programs under a one health approach that consider the health of people, animals, and the environment.

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“…in the host cutaneous tissue. This is considered an implantation mycosis that can occur through an animal or environmental transmission route [ 4 , 5 , 6 , 7 ]. Sporothrix spp.…”

Section: Introductionmentioning

confidence: 99%

Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

Thomson

González

Blank³

et al. 2023

JoF

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“… 5 , 10 , 14 , 15 Historically, S. schenckii was the first fungal species associated with sporotrichosis, and as a consequence, it is the Sporothrix species most thoroughly studied at both basic and clinical levels. 3 , 16 S. globosa , like S. schenckii , is distributed worldwide; 4 however, within the pathogenic clade is considered the least virulent species due to its limited growth at high temperatures. 17–19 S. brasiliensis has been responsible for infectious outbreaks in Brazil and is considered the most virulent species.…”

Section: Introductionmentioning

confidence: 99%

Differential Recognition of Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa by Human Monocyte-Derived Macrophages and Dendritic Cells

Gómez-Gaviria¹,

Martínez-Duncker²,

García-Carnero³

et al. 2023

IDR

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Background Sporotrichosis is a mycosis frequently caused by Sporothrix schenckii, Sporothrix brasiliensis , and Sporothrix globosa . The cell wall is a species-specific fungal structure with a direct role in activating the host’s immune response. The current knowledge about anti- Sporothrix immunity comes from studies using S. schenckii or S. brasiliensis and murine cells. Macrophages and dendritic cells detect and eliminate pathogens, and although the function of these cells links innate with adaptive immunity, little is known about their interaction with Sporothrix spp. Methods S. schenckii, S. brasiliensis , and S. globosa conidia or yeast-like cells were co-incubated with human monocyte-derived macrophages or dendritic cells, and the phagocytosis and cytokine stimulation were assessed. These interactions were also performed in the presence of specific blocking agents of immune receptors or fungal cells with altered walls to analyze the contribution of these molecules to the immune cell-fungus interaction. Results Both types of immune cells phagocytosed S. globosa conidia and yeast-like cells to a greater extent, followed by S. brasiliensis and S. schenckii . Furthermore, when the wall internal components were exposed, the phagocytosis level increased for S. schenckii and S. brasiliensis , in contrast to S. globosa . Thus, the cell wall components have different functions during the interaction with macrophages and dendritic cells. S. globosa stimulated an increased proinflammatory response when compared to the other species. In macrophages, this was a dectin-1-, mannose receptor-, and TLR2-dependent response, but dectin-1- and TLR2-dependent stimulation in dendritic cells. For S. schenckii and S. brasiliensis , cytokine production was dependent on the activation of TLR4, CR3, and DC-SIGN. Conclusion The results of this study indicate that these species are recognized by immune cells differently and that this may depend on both the structure and cell wall organization of the different morphologies.

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“…The parasite spreads through the lymphatic circulation, simultaneously causing skin lesions. The infection affects the skin, subcutaneous tissues, the lymphatic system, and rarely the deep-seated organs 3 . Zoonotic outbreaks have been described in Brazil, where the disease is transmitted by cats, with S. brasiliensis being the species involved 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Severe form of lymphocutaneous sporotrichosis: a case report

Martins,

Durães,

Teixeira

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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Sporotrichosis is the most frequent subcutaneous mycosis in Latin America. It is caused by species of the genus Sporothrix. Infection in humans occurs through the entry of the fungus into the skin. Zoonotic outbreaks involving cats in the transmission of the disease have been frequently reported. The lymphocutaneous form is the most commonly observed and the upper limbs are the most affected sites. We report a case of a 64-year-old healthy female patient with a lymphocutaneous form with rapid progression of lesions, which was refractory to initial treatment with itraconazole. Treatment with liposomal amphotericin B was performed with a satisfactory resolution, but aesthetic and functional sequelae in the left upper limb were installed.

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Special Issue “Sporothrix and Sporotrichosis 2.0”

Abstract: Sporotrichosis is a chronic fungal disease of humans and other mammals that often affects the skin and subcutaneous tissues and, rarely, deep-seated organs (most frequently in immunocompetent hosts) [...]

Cited by 9 publications

References 33 publications

Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

Differential Recognition of Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa by Human Monocyte-Derived Macrophages and Dendritic Cells

Severe form of lymphocutaneous sporotrichosis: a case report

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