Special Issue “Saliva and Oral Diseases”

Jornet, Pía López

doi:10.3390/jcm9061955

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Its secretion is regulated by the autonomic nervous system. Whole saliva or oral fluid refers to the liquid made up of salivary gland secretion, crevicular fluid, epithelial cells shed from the oral mucosa, and food debris [ 9 ]. Other components may include DNA, proteins, metabolites, RNA, and microbiota which have been proposed as biomarkers of certain diseases.…”

Section: Introductionmentioning

confidence: 99%

Advances in the Diagnosis, Monitoring, and Progression of Oral Cancer through Saliva: An Update

Rodríguez-Molinero

Migueláñez-Medrán

Delgado-Somolinos

et al. 2022

BioMed Research International

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The early detection of cancer, and in particular oral cancer, has been a priority objective of study in recent years. Saliva has been proposed as an easy-to-obtain means of providing the necessary information to diagnose malignant lesions in the oral cavity, since it can be obtained very easily and completely noninvasively. There are a number of molecules, known as biomarkers, which may be involved in the malignant transformation of oral lesions, and which have different natures. The involvement of proteins (“proteomics”), metabolites (“metabolomics”), and even certain genes in the structural changes of altered tissue has been investigated in order to establish validated parameters for the early diagnosis of oral cancer. In addition, the development of new analytical assay methods that can reduce costs and obtain better results in terms of sensitivity and specificity has been a key point in recent research in this field. Even though there are numerous biomarkers with results showing high sensitivity and specificity, there is still a need for more studies, with a larger sample and with analytical methods that can constitute a real advance in time and cost. Although salivary biomarkers are a promising new diagnostic tool for oral cancer, for the moment they do not replace biopsy as the “gold standard”.

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Section: Introductionmentioning

confidence: 99%

Advances in the Diagnosis, Monitoring, and Progression of Oral Cancer through Saliva: An Update

Rodríguez-Molinero

Migueláñez-Medrán

Delgado-Somolinos

et al. 2022

BioMed Research International

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“…As a rich reservoir of proteins, especially glycoproteins, electrolytes, lipids and other molecules with several biological functions, saliva plays a pivotal role in the maintenance of oral homeostasis and mucosal integrity [ 5 ]. Changes in its constituents offers an active field for researchers to discover novel and useful biomarkers (‘salivaomics’) [ 6 ]. Saliva and its samplings have several advantages compared to other body fluids such as being non-invasive, painless, cost-efficient for diagnosis with possibility of self-collection which is particularly advantageous in a pandemic period [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Salivary Osteopontin as a Potential Biomarker for Oral Mucositis

et al. 2021

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Osteopontin (OPN), a multifunctional phosphoglycoprotein also presents in saliva, plays a crucial role in tumour progression, inflammation and mucosal protection. Mucosal barrier injury due to high-dose conditioning regimen administered during autologous and allogeneic peripheral stem cell transplantation (APSCT) has neither efficient therapy nor established biomarkers. Our aim was to assess the biomarker role of OPN during APSCT, with primary focus on oral mucositis (OM). Serum and salivary OPN levels were determined by ELISA in 10 patients during APSCT at four stages of transplantation (day −3/−7, 0, +7, +14), and in 23 respective healthy controls. Results: There was a negative correlation between both salivary and serum OPN levels and grade of OM severity during APSCT (r = −0.791, p = 0.019; r = −0.973, p = 0.001). Salivary OPN increased at days +7 (p = 0.011) and +14 (p = 0.034) compared to controls. Among patients, it was higher at day +14 compared to the time of admission (day −3/−7) (p = 0.039) and transplantation (day 0) (p = 0.011). Serum OPN remained elevated at all four stages of transplantation compared to controls (p = 0.013, p = 0.02, p = 0.011, p = 0.028). During APSCT elevated salivary OPN is a potential non-invasive biomarker of oral mucositis whereas the importance of high serum OPN warrants further studies.

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Special Issue “Saliva and Oral Diseases”

Abstract: The discovery of microbial, immunological or molecular markers in saliva offers unique opportunities, and has caused our view of saliva to change drastically in recent years [...]

Cited by 2 publications

References 9 publications

Advances in the Diagnosis, Monitoring, and Progression of Oral Cancer through Saliva: An Update

Advances in the Diagnosis, Monitoring, and Progression of Oral Cancer through Saliva: An Update

Salivary Osteopontin as a Potential Biomarker for Oral Mucositis

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