“…Their ability to successfully accelerate and improve the quality of skin wound healing has been widely demonstrated in animal studies and clinical trials (Wu et al, 2007;Clover et al, 2014;Formigli et al, 2015;Zomer et al, 2020;Kerstan et al, 2022). MSCs secrete multiple cytokines and growth factors with antiinflammatory, angiogenic, proliferative, migratory and antiapoptotic effects which have been linked to their broad therapeutic application (Jo et al, 2021). It has been shown that MSCs increase tensile strength through a macrophage-dependent mechanism in wound healing in old mice, restoring the strength levels seen in younger adult mice (Lee et al, 2013).…”