Special Issue on Nano-Biointerface for Biosensing

Satriano, Cristina

doi:10.3390/app9214504

Cited by 2 publications

(4 citation statements)

References 15 publications

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“…Figure 10(a) shows the SEM image of silver nanoparticles reacting with chloroauric acid according to the sequence of free energy of crystallography: The gold and silver nanoparticles formed by this method act a pivotal part in recatalysis, sensing and other fields. [45] Wang et al synthesized a novel anion water-soluble inclined column [6] aromatics (AWLP6) with good cavity adaptability. AWLP6 was used as reducing agent and the best stabilizer, and AWLP6-AuNPs was synthesized in situ by onestep method.…”

Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

“…Because of the excellent biocompatibility, low toxicity and tunable stability have been successfully used in the fields of the biosensor, bioimaging, medical diagnosis, and treatment. [4][5][6] Even nanoparticles functionalized with polyethylene glycol have been used for photothermal treatment of cancer. [7] In this paper, the classical synthesis methods of functional gold nanoparticles and the improvement of Turkevich and Brust-Schiffrin methods by some research groups are reviewed.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the in‐depth study on the preparation, assembly, properties, and applications of gold nanoparticles has been widely concerned. Because of the excellent biocompatibility, low toxicity and tunable stability have been successfully used in the fields of the biosensor, bioimaging, medical diagnosis, and treatment [4–6] . Even nanoparticles functionalized with polyethylene glycol have been used for photothermal treatment of cancer [7] …”

Section: Introductionmentioning

confidence: 99%

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Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications

Fan

Cheng

Sun

2020

The Chemical Record

115

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Gold nanoparticles have excellent optical and plasmon properties and have enormous research potential when they combine with different ligands. Functionalized gold nanoparticles are widely used in drug delivery, biological detection, sensors, and even clinical treatment. At present, with the rapid development of functionalized gold nanoparticles, we think it is necessary to sort out the recent research results. In this paper, the synthesis, characteristics, and biological applications of the three aspects are introduced. Firstly, the synthetic methods of functionalized gold nanoparticles are reviewed, and the improvement of the commonly used synthetic methods is summarized. Then, the catalytic properties, oxidation resistance, and chirality optical properties are summarized in detail. Finally, we summarize the research progress in the field of biology in recent years.

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Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications

Fan

Cheng

Sun

2020

The Chemical Record

115

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“…To this respect, spherical citrated-capped AuNPs in the size range of 10-50 nm have been considered as non-toxic towards several human cell lines [10][11][12][13]. In addition, their easy synthesis [14] and functionalization with a variety of biomolecular ligands [15] as well as no susceptibility to the photobleaching or chemical/thermal denaturation mostly associated with common dyes [16], make them suitable for application in biochemical sensing, medical diagnostics and therapeutic strategies [17][18][19]. To be noted, PEGylated gold nanoparticles have been approved by the Food and Drug Administration for photothermal cancer therapy [20].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan-Metal Gold Nanoparticle Hybrids for Targeted Tumor Cell Therapy

Sanfilippo

Caruso

Cucci

et al. 2020

IJMS

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In this study, a novel multifunctional nanoplatform based on core-shell nanoparticles of spherical gold nanoparticles (AuNPs) capped with low and high molecular weight (200 and 700 kDa) hyaluronic acid (HA), was assembled via a green, one-pot redox synthesis method at room temperature. A multitechnique characterization approach by UV-visible spectroscopy, dynamic light scattering and atomic force microscopy pointed to the effective ‘surface decoration’ of the gold nanoparticles by HA, resulting in different grafting densities of the biopolymer chains at the surface of the metal nanoparticle, which in turn affected the physicochemical properties of the nanoparticles. Specifically, the spectral features of the gold plasmonic peak (and the related calculated optical size), the hydrodynamic diameter and the nanoparticle stability were found to depend on the molecular weight of the HA. The CD44-targeting capability of HA-functionalized gold nanoparticles was tested in terms of antibacterial activity and cytotoxicity. An enhanced inhibitory activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus was found, with a HA molecular weight (MW)-dependent trend for the HA-capped AuNPs compared to the bare, glucose-capped AuNPs. Cell viability assays performed on two CD44-positive cell models, namely normal human umbilical vein endothelial (HUVEC) and prostate tumor (PC-3) cells, in comparison with neuroblastoma cells (SH-SY5Y), which do not express the CD44 receptor, demonstrated an increased cytotoxicity in neuroblastoma compared to prostate cancer cells upon the cellular treatments by HA–AuNP compared to the bare AuNP, but a receptor-dependent perturbation effect on cytoskeleton actin and lysosomal organelles, as detected by confocal microscopy. These results highlighted the promising potentialities of the HA-decorated gold nanoparticles for selective cytotoxicity in cancer therapy. Confocal microscopy imaging of the two human tumor cell models demonstrated a membrane-confined uptake of HA-capped AuNP in the cancer cells that express CD44 receptors and the different perturbation effects related to molecular weight of HA wrapping the metallic core of the plasmonic nanoparticles on cellular organelles and membrane mobility.

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Special Issue on Nano-Biointerface for Biosensing

Abstract: Point-of-care nanobiosensors have tremendous potential to revolutionize the future of personalized nanomedicine, especially for the simultaneous diagnosis and therapy, which takes the name of theranostics [...]

Cited by 2 publications

References 15 publications

Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications

Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications

Hyaluronan-Metal Gold Nanoparticle Hybrids for Targeted Tumor Cell Therapy

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