Special Issue: Nanomedicine Advances in Infectious Disease

Peters, Erica B.; Banerjee, Rinti

doi:10.1021/acsbiomaterials.1c00521

Cited by 1 publication

(2 citation statements)

References 13 publications

(13 reference statements)

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“…Such advancements facilitate efficient drug delivery to tumors, optimize drug distribution within organisms, and improve therapeutic outcomes, while minimizing adverse effects on normal tissues [121,122]. However, the metabolism and excretion mechanisms of nanomedicines differ markedly from those of traditional drugs, potentially leading to accumulation within organisms and consequent long-term toxicity issues [123]. Furthermore, the size and surface characteristics of nanoparticles may influence their ability to navigate through hepatic, renal, or other excretory pathways, affecting not only the drug clearance rate but also the overall safety and efficacy of the therapeutic regimen [124].…”

Section: Role Of Nanomedicine In Ndtmentioning

confidence: 99%

“…Furthermore, the size and surface characteristics of nanoparticles may influence their ability to navigate through hepatic, renal, or other excretory pathways, affecting not only the drug clearance rate but also the overall safety and efficacy of the therapeutic regimen [124]. the metabolism and excretion mechanisms of nanomedicines differ markedly from those of traditional drugs, potentially leading to accumulation within organisms and consequent long-term toxicity issues [123]. Furthermore, the size and surface characteristics of nanoparticles may influence their ability to navigate through hepatic, renal, or other excretory pathways, affecting not only the drug clearance rate but also the overall safety and efficacy of the therapeutic regimen [124].…”

Section: Role Of Nanomedicine In Ndtmentioning

confidence: 99%

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Advances in Nanodynamic Therapy for Cancer Treatment

Zhang,

Huang,

Huang

2024

Nanomaterials

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Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity by leveraging the tumor microenvironment (TME) and mechanisms that boost anti-tumor immune responses. It also minimizes damage to surrounding healthy tissues and enhances cytotoxicity in tumor cells, showing promise in cancer treatment, with significant potential. This review covers the research progress in five major nanodynamic therapies: photodynamic therapy (PDT), electrodynamic therapy (EDT), sonodynamic therapy (SDT), radiodynamic therapy (RDT), and chemodynamic therapy (CDT), emphasizing the significant role of advanced nanotechnology in the development of NDT for anti-tumor purposes. The mechanisms, effects, and challenges faced by these NDTs are discussed, along with their respective solutions for enhancing anti-tumor efficacy, such as pH response, oxygen delivery, and combined immunotherapy. Finally, this review briefly addresses challenges in the clinical translation of NDT.

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