Special Issue: MicroRNA Regulation in Health and Disease

Subramanian, Subbaya; Steer, Clifford J.

doi:10.3390/genes10060457

Cited by 23 publications

(9 citation statements)

References 15 publications

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“…The human genome encodes about 2000 miRNAs, which target 30–60% of the genes [ 38 ]. MicroRNAs are commonly deregulated in numerous diseases and are currently intensely studied, including in NAFLD [ 39 ]. Chromosome 1 encodes 134 miRs, followed by the X chromosome, which encodes 116 miRs [ 40 ].…”

Section: Epigenetics Of Nafld: Noncoding Rnas (Ncrnas)mentioning

confidence: 99%

Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide in part due to the concomitant obesity pandemic and insulin resistance (IR). It is increasingly becoming evident that NAFLD is a disease affecting numerous extrahepatic vital organs and regulatory pathways. The molecular mechanisms underlying the nonalcoholic steatosis formation are poorly understood, and little information is available on the pathways that are responsible for the progressive hepatocellular damage that follows lipid accumulation. Recently, much research has focused on the identification of the epigenetic modifications that contribute to NAFLD pathogenesis. Noncoding RNAs (ncRNAs) are one of such epigenetic factors that could be implicated in the NAFLD development and progression. In this review, we summarize the current knowledge of the genetic and epigenetic factors potentially underlying the disease. Particular emphasis will be put on the contribution of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) to the pathophysiology of NAFLD as well as their potential use as therapeutic targets or as markers for the prediction and the progression of the disease.

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Section: Epigenetics Of Nafld: Noncoding Rnas (Ncrnas)mentioning

confidence: 99%

Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers

et al. 2020

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“…Furthermore, the study of multiple clinical markers in MDD are reporting a substantial growing in the last years, in order to identify the therapeutic success of the treatment regimen, also aiding to predict long-term outcomes [ 19 ]. The study of micro RNAs (miRNAs) represent a central point in the growing field of epigenetics, being considered as a central point to understand health and disease conditions [ 20 , 21 ]. Thus, the aim of this review is to collect the updated knowledge of the miRNAs more strongly supported by the scientific evidence in MDD, exploring the different links between miRNAs with the onset and progression of MDD, as well as examining promising translational implications in this area.…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective

et al. 2021

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Major Depressive Disorder (MDD) represents a major global health concern, a body-mind malady of rising prevalence worldwide nowadays. The complex network of mechanisms involved in MDD pathophysiology is subjected to epigenetic changes modulated by microRNAs (miRNAs). Serum free or vesicles loaded miRNAs have starred numerous publications, denoting a key role in cell-cell communication, systematically and in brain structure and neuronal morphogenesis, activity and plasticity. Upregulated or downregulated expression of these signaling molecules may imply the impairment of genes implicated in pathways of MDD etiopathogenesis (neuroinflammation, brain-derived neurotrophic factor (BDNF), neurotransmitters, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, circadian rhythms...). In addition, these miRNAs could serve as potential biomarkers with diagnostic, prognostic and predictive value, allowing to classify severity of the disease or to make decisions in clinical management. They have been considered as promising therapy targets as well and may interfere with available antidepressant treatments. As epigenetic malleable regulators, we also conclude emphasizing lifestyle interventions with physical activity, mindfulness and diet, opening the door to new clinical management considerations.

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“…Noncoding RNAs are a group of RNA molecules without protein-coding capacity, involved in chromatin remodeling and in transcriptional and post-transcriptional gene regulation [ 23 ]. Among noncoding RNAs, especially the microRNAs (miRNA) are deregulated in NAFLD, and several studies have shown the association of miRNAs with liver steatosis [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease: Focus on New Biomarkers and Lifestyle Interventions

Notarnicola

Osella

Caruso

et al. 2021

IJMS

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Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome, characterized from pathological changes in lipid and carbohydrate metabolism. Its main characteristics are excessive lipid accumulation and oxidative stress, which create a lipotoxic environment in hepatocytes leading to liver injury. Recently, many studies have focused on the identification of the genetic and epigenetic modifications that also contribute to NAFLD pathogenesis and their prognostic implications. The present review is aimed to discuss on cellular and metabolic alterations associated with NAFLD, which can be helpful to identify new noninvasive biomarkers. The identification of accumulated lipids in the cell membranes, as well as circulating cytokeratins and exosomes, provides new insights in understanding of NAFLD. This review also suggests that lifestyle modifications remain the main prevention and/or treatment for NAFLD.

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Special Issue: MicroRNA Regulation in Health and Disease

Abstract: Our understanding of non-coding RNA has significantly changed based on recent advances in genomics and molecular biology, and their role is recognized to include far more than a link between the sequence of DNA and synthesized proteins [...]

Cited by 23 publications

References 15 publications

Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers

Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers

MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective

Nonalcoholic Fatty Liver Disease: Focus on New Biomarkers and Lifestyle Interventions

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