Special Issue: “Innate Immunity to Virus Infection, 1st Edition”

Wang, Congcong; Ma, Feng; Sun, Caijun

doi:10.3390/v15102060

Cited by 1 publication

(1 citation statement)

References 14 publications

(14 reference statements)

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“…The first line of immune response is innate immunity, which is primarily formed by macrophages, antigen-presenting cells (APCs), innate lymphoid cells (ILCs), and a variety of non-immune cells. Innate immunity is initiated via the recognition of conserved pathogen-associated molecular patterns (PAMPs) by cellular pattern recognition receptors (PRRs) in host cells [ 5 , 6 ]. Invading nucleic acids, such as viral RNA or DNA, are recognized by different PRRs, which trigger signaling pathways and ultimately induce the expression of type I interferons (IFN-Is), proinflammatory cytokines, and other antiviral effector genes [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies

Wu,

Wang,

et al. 2024

Viruses

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Previous studies reported that the association between statins use and influenza infection was contradictory. A systematic review and meta-analysis of longitudinal studies were performed to determine the association between statins use and influenza susceptibility. The literature search was conducted in PubMed, Embase, and Web of Science, from each database’s inception to 21 May 2023. The fixed effect model and random effects model were used for data synthesis. In our study, a total of 1,472,239 statins users and 1,486,881 statins non-users from five articles were included. The pooled risk ratio (RR) of all included participants was 1.05 (95% CI: 1.03–1.07,) and there were still significant differences after adjusting for vaccination status. Of note, RR values in statins users were 1.06 (95% CI: 1.03–1.08) in people aged ≥60 years old and 1.05 (95% CI: 1.03–1.07) in participant groups with a higher proportion of females. Administration of statins might be associated with an increased risk of influenza infection, especially among females and elderly people. For those people using statins, we should pay more attention to surveillance of their health conditions and take measures to prevent influenza infection.

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