Special Issue: From Natural Polyphenols to Synthetic Bioactive Analogues

Tringali, Corrado

doi:10.3390/molecules25122772

Cited by 5 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The metabolization of polyphenols, a critical process for unlocking their bioactive potential, begins as these compounds enter the intricate pathways of the human digestive system. The efficiency of polyphenol absorption is influenced by various physicochemical factors, including the size of the molecule, the presence of functional groups, its spherical shape, lipophilicity, and solubility [183]. Once absorbed, the phenolic compounds are the subject of intense metabolization, which leads to metabolites with more bioavailability than the phenolic compounds [184].…”

Section: Polyphenolic Compounds Metabolization and Their Significance...mentioning

confidence: 99%

Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging

Pereira,

Fortunato,

Oliveira

et al. 2024

Nutrients

View full text Add to dashboard Cite

In the aging process, physiological decline occurs, posing a substantial threat to the physical and mental well-being of the elderly and contributing to the onset of age-related diseases. While traditional perspectives considered the maintenance of life as influenced by a myriad of factors, including environmental, genetic, epigenetic, and lifestyle elements such as exercise and diet, the pivotal role of symbiotic microorganisms had been understated. Presently, it is acknowledged that the intestinal microbiota plays a profound role in overall health by signaling to both the central and peripheral nervous systems, as well as other distant organs. Disruption in this bidirectional communication between bacteria and the host results in dysbiosis, fostering the development of various diseases, including neurological disorders, cardiovascular diseases, and cancer. This review aims to delve into the intricate biological mechanisms underpinning dysbiosis associated with aging and the clinical ramifications of such dysregulation. Furthermore, we aspire to explore bioactive compounds endowed with functional properties capable of modulating and restoring balance in this aging-related dysbiotic process through epigenetics alterations.

show abstract

Section: Polyphenolic Compounds Metabolization and Their Significance...mentioning

confidence: 99%

Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging

Pereira,

Fortunato,

Oliveira

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Therefore, the in-depth investigation of the mechanism and drug discovery is still essential in the future. Polyphenols are complex plant secondary metabolites, which are mainly from dietary plants and exhibit a variety of pharmacological activities, such as antioxidant, antiinflammatory, anticancer, liver protection, and neuroprotection [140,449,450]. Although most of the polyphenols are demonstrated to exhibit neuroprotective effects in various Oxidative Medicine and Cellular Longevity cellular and animal models, there are still very limited polyphenols or plant extracts that are developed into new drugs for the treatment of neurodegenerative diseases.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities

Guo

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), are characterized by the progressive degeneration of neurons. Although the etiology and pathogenesis of neurodegenerative diseases have been studied intensively, the mechanism is still in its infancy. In general, most neurodegenerative diseases share common molecular mechanisms, and multiple risks interact and promote the pathologic process of neurogenerative diseases. At present, most of the approved drugs only alleviate the clinical symptoms but fail to cure neurodegenerative diseases. Numerous studies indicate that dietary plant polyphenols are safe and exhibit potent neuroprotective effects in various neurodegenerative diseases. However, low bioavailability is the biggest obstacle for polyphenol that largely limits its adoption from evidence into clinical practice. In this review, we summarized the widely recognized mechanisms associated with neurodegenerative diseases, such as misfolded proteins, mitochondrial dysfunction, oxidative damage, and neuroinflammatory responses. In addition, we summarized the research advances about the neuroprotective effect of the most widely reported dietary plant polyphenols. Moreover, we discussed the current clinical study and application of polyphenols and the factors that result in low bioavailability, such as poor stability and low permeability across the blood-brain barrier (BBB). In the future, the improvement of absorption and stability, modification of structure and formulation, and the combination therapy will provide more opportunities from the laboratory into the clinic for polyphenols. Lastly, we hope that the present review will encourage further researches on natural dietary polyphenols in the treatment of neurodegenerative diseases.

show abstract

Dietary Natural Polyphenols Against Bacterial and Fungal Infections: An Emerging Gravity in Health Care and Food Industry

Patra,

Das,

Shamim

et al. 2023

Bioprospecting of Tropical Medicinal Plants

View full text Add to dashboard Cite

Special Issue: From Natural Polyphenols to Synthetic Bioactive Analogues

Cited by 5 publications

References 5 publications

Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging

Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging

Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities

Dietary Natural Polyphenols Against Bacterial and Fungal Infections: An Emerging Gravity in Health Care and Food Industry

Contact Info

Product

Resources

About