Special Issue “Emerging Viruses: Surveillance, Prevention, Evolution, and Control”

Campos, Fabrício Souza; Arruda, Luciana Barros de; Fonseca, Flávio Guimarães da

doi:10.3390/v12030306

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…However, the bene cial clinical outcomes observed in the study hold special signi cance in the present era with reimerging and recurring viral infections. 27,28 Overall the ndings of this study support the exploratory notions of several researchers and clinicians that certain meditation, yoga asana (postures), and pranayama (breathing) practices may be effective adjunctive means of treating SARS-CoV-2 infection. 12 The ndings also pave the foundation for the clinical implementation of tele-yoga-based adjunct interventions in hospital settings for the management of infectious diseases.…”

Section: Discussionsupporting

confidence: 74%

Effect of Adjunct Tele-Yoga on Clinical Status at 14 Days in Hospitalized mild and Moderate COVID-19 Patients: a Randomized Controlled Trial

Majumdar

Nagarathna

Panigrahi

et al. 2022

Preprint

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Background: We tested if tele-yoga intervention could aid in better clinical management for hospitalized patients with mild to moderate COVID-19 when complemented with the standard of care.Methods: This was a randomized controlled trial conducted at the Narayana Hrudalaya, Bengaluru, India on hospitalized patients with mild to moderate COVID-19 infection, enrolled between May 31st and July 22, 2021. Patients (n=225) were randomized in 1:1 ratio [adjunct tele-yoga (n = 113), or standard of care (n = 112)]. Adjunct yoga group received intervention in tele-mode within 4 hours post-randomization until 14 days along with the standard of care. The primary outcome was clinical status at 14th-day post-randomization assessed with a 7-category ordinal scale. The trial included 11 secondary outcomes, including 28-day mortality.Results: As compared with standard of care alone, the proportional odds of having a higher score on the seven-point ordinal scale at day 14 was ~1.9 for the adjunct tele-yoga group (95% CI, 1.18-3.18). CRP and LDH levels were comparatively reduced in the adjunct tele-yoga group 5th day post-randomization. CRP reduction was also observed as a potential mediator for the improvement of clinical outcomes in the adjunct tele-yoga group. There were no significant differences between the treatment groups concerning the duration of hospitalization, all-cause mortality at day 28; log-rank P = 0.144, and other outcomes.Conclusion: The observed clinically relevant outcomes in COVID-19 patients at day 14 contest the use of tele-yoga as a complementary treatment in hospital settings.

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Section: Discussionsupporting

confidence: 74%

Effect of Adjunct Tele-Yoga on Clinical Status at 14 Days in Hospitalized mild and Moderate COVID-19 Patients: a Randomized Controlled Trial

Majumdar

Nagarathna

Panigrahi

et al. 2022

Preprint

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“…We speculate that the failure to obtain the desired effect on stress and several other variables could be due to the primarily virtual mode of the delivery of the intervention and the short duration of the intervention. However, the beneficial clinical outcomes observed in the study hold special significance in the present era with reemerging and recurring viral infections ( 27 , 28 ). Overall, the findings of this study support the exploratory notions of several researchers and clinicians that certain meditation, yoga asana (postures), and pranayama (breathing) practices may be effective adjunctive means of treating SARS-CoV-2 infection ( 12 ).…”

Section: Discussionmentioning

confidence: 84%

Adjunct tele-yoga on clinical status at 14 days in hospitalized patients with mild and moderate COVID-19: A randomized control trial

Majumdar

Nagarathna²,

Panigrahi³

et al. 2023

Front. Public Health

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BackgroundThe initial insights from the studies on COVID-19 had been disappointing, indicating the necessity of an aggravated search for alternative strategies. In this regard, the adjunct potential of yoga has been proposed for enhancing the effectiveness of the standard of care with respect to COVID-19 management. We tested whether a telemodel of yoga intervention could aid in better clinical management for hospitalized patients with mild-to-moderate COVID-19 when complemented with the standard of care.MethodsThis was a randomized controlled trial conducted at the Narayana Hrudyalaya, Bengaluru, India, on hospitalized patients with mild-to-moderate COVID-19 infection enrolled between 31 May and 22 July 2021. The patients (n = 225) were randomized in a 1:1 ratio [adjunct tele-yoga (n = 113) or standard of care]. The adjunct yoga group received intervention in tele-mode within 4-h post-randomization until 14 days along with the standard of care. The primary outcome was the clinical status on day 14 post-randomization, assessed with a seven-category ordinal scale. The secondary outcome set included scores on the COVID Outcomes Scale on day 7, follow-up for clinical status and all-cause mortality on day 28, post-randomization, duration of days at the hospital, 5th-day changes post-randomization for viral load expressed as cyclic threshold (Ct), and inflammatory markers and perceived stress scores on day 14.ResultsAs compared with the standard of care alone, the proportional odds of having a higher score on the 7-point ordinal scale on day 14 were ~1.8 for the adjunct tele-yoga group (OR = 1.83, 95% CI, 1.11–3.03). On day 5, there were significant reductions in CRP (P = 0.001) and LDH levels (P = 0.029) in the adjunct yoga group compared to the standard of care alone. CRP reduction was also observed as a potential mediator for the yoga-induced improvement of clinical outcomes. The Kaplan–Meier estimate of all-cause mortality on day 28 was the adjusted hazard ratio (HR) of 0.26 (95% CI, 0.05–1.30).ConclusionThe observed 1.8-fold improvement in the clinical status on day 14 of patients of COVID-19 with adjunct use of tele-yoga contests its use as a complementary treatment in hospital settings.

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“…New diseases have emerged from the beginning of the 21st century, viz., SARS-CoV-2, Middle east respiratory syndrome coronavirus (MERS-CoV), H1N1 swine influenza, Ebola virus, Zika virus, and Nipah virus, etc., which are life-threatening to humankind [ 1 , 2 ]. The researchers were able to stop these diseases from spreading over the world or found successful drugs to inhibit them.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Anti-HIV Phytocompounds against SARS-CoV-2 Main Protease: Structure-Based Screening, Molecular Simulation, ADME Analysis and Conceptual DFT Studies

Murali

Gowtham²,

Shilpa

et al. 2022

Molecules

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The ever-expanding pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has gained attention as COVID-19 and caused an emergency in public health to an unmatched level to date. However, the treatments used are the only options; currently, no effective and licensed medications are available to combat disease transmission, necessitating further research. In the present study, an in silico-based virtual screening of anti-HIV bioactive compounds from medicinal plants was carried out through molecular docking against the main protease (Mpro) (PDB: 6LU7) of SARS-CoV-2, which is a key enzyme responsible for virus replication. A total of 16 anti-HIV compounds were found to have a binding affinity greater than −8.9 kcal/mol out of 150 compounds screened. Pseudohypericin had a high affinity with the energy of −10.2 kcal/mol, demonstrating amino acid residual interactions with LEU141, GLU166, ARG188, and GLN192, followed by Hypericin (−10.1 kcal/mol). Moreover, the ADME (Absorption, Distribution, Metabolism and Excretion) analysis of Pseudohypericin and Hypericin recorded a low bioavailability (BA) score of 0.17 and violated Lipinski’s rule of drug-likeness. The docking and molecular simulations indicated that the quinone compound, Pseudohypericin, could be tested in vitro and in vivo as potent molecules against COVID-19 disease prior to clinical trials.This was also supported by the theoretical and computational studies conducted. The global and local descriptors, which are the underpinnings of Conceptual Density FunctionalTheory (CDFT) have beenpredicted through successful model chemistry, hoping that they could be of help in the comprehension of the chemical reactivity properties of the molecular systems considered in this study.

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Special Issue “Emerging Viruses: Surveillance, Prevention, Evolution, and Control”

Abstract: Emerging viruses represent a major concern for public health offices [...]

Cited by 7 publications

References 39 publications

Effect of Adjunct Tele-Yoga on Clinical Status at 14 Days in Hospitalized mild and Moderate COVID-19 Patients: a Randomized Controlled Trial

Effect of Adjunct Tele-Yoga on Clinical Status at 14 Days in Hospitalized mild and Moderate COVID-19 Patients: a Randomized Controlled Trial

Adjunct tele-yoga on clinical status at 14 days in hospitalized patients with mild and moderate COVID-19: A randomized control trial

Exploration of Anti-HIV Phytocompounds against SARS-CoV-2 Main Protease: Structure-Based Screening, Molecular Simulation, ADME Analysis and Conceptual DFT Studies

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