Special Issue “C-Reactive Protein and Cardiovascular Disease: Clinical Aspects”

Sheriff, Ahmed

doi:10.3390/jcm11133610

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…Hs-CRP, detected through an ultrasensitive technique, can reveal even lower levels of CRP. CRP has been associated with both CVD and major adverse cardiac events 48. Additionally, a higher level of IL-6 is associated with an increased risk of atherosclerotic CVD 49…”

Section: Discussionmentioning

confidence: 99%

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Meta-analysis on inflammation and autonomic nervous system of coronary heart disease combined with depression

Li,

Zhang,

Liu

2024

BMJ Open

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ObjectivesThis meta-analysis aimed to explore the association between inflammatory factors, heart rate variability (HRV) and the coexistence of coronary heart disease (CHD) and depression.DesignSystematic review and meta-analysis. Complying with the Meta-analysis Of Observational Studies in Epidemiology statement.Data sourcesWe searched PubMed, Web of Science and EMBASE for the data from the inception date to 16 March 2023.Eligibility criteriaWe included cross-sectional and cohort studies with inclusion criteria: (1) patients with CHD; (2) depression measurement and (3) including inflammatory factors or cardiac biomarkers or HRV.Data extraction and synthesisTwo authors searched the databases independently. The effect estimates and heterogeneity were synthesised by Review Manager V.5.3. Sensitivity analysis and publication bias were analysed by STATA software. The quantitative synthesis outcomes were presented by mean difference (MD) or standard MD (SMD) with 95% CI.ResultsBy searching the databases, we identified a total of 6750 articles. There were 22 articles left after selection, including 6344 participants. This meta-analysis indicated that patients with CHD with depression had higher levels of C reaction protein (CRP) (SMD 0.50, 95% CI (0.19 to 0.81), p=0.001), high-sensitivity C reactive protein (hs-CRP) (SMD 0.28, 95% CI (0.07 to 0.48), p=0.008), IL-6 (SMD 0.49, 95% CI (0.05 to 0.92), p=0.03) and a lower level of the mean RR interval and the SD of all RR intervals (SMD −0.64, 95% CI (−1.11 to –0.17), p=0.008), SD of the 5 min averages of all normal RR intervals (MD −12.77 ms, 95% CI (–21.20 to –4.33), p=0.003), overage of the SD of all normal RR intervals for each 5 min segment (MD −13.83 ms, 95% CI (–15.94 to –11.72), p<0.00001), root mean square of successive differences (MD: −8.02 ms, 95% CI (–13.62 to –2.43), p=0.005), proportion of adjacent cycles differing by >50 ms (pNN50) (SMD −0.86, 95% CI (−1.41 to –0.31), p=0.002), than those without depression.ConclusionsThis study underscores the association between elevated CRP, hs-CRP, IL-6 and lower HRV in patients with CHD with depression. It emphasises the importance of clinicians assessing CRP, hs-CRP, IL-6 and HRV in patients with CHD to potentially identify depressive conditions.

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Section: Discussionmentioning

confidence: 99%

“…CRP has been associated with both CVD and major adverse cardiac events. 48 Additionally, a higher level of IL-6 is associated with an increased risk of atherosclerotic CVD. 49 Furthermore, inflammation has been established as a crucial factor linking CHD and depression.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis on inflammation and autonomic nervous system of coronary heart disease combined with depression

Li,

Zhang,

Liu

2024

BMJ Open

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“…CRP has been identified to be associated with CVD and major adverse cardiac events. [39] In addition, a higher level of IL-6 is associated with a higher risk of atherosclerotic cardiovascular disease (ASCVD). [40] Moreover, inflammation has been established to be a vital factor in linking CHD and depression.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis on inflammation and autonomic nervous system of coronary heart disease combined with depression

Zhang

2023

Preprint

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Objective This meta-analysis aimed to explore the association between inflammatory factors, HRV, and the coexistence of coronary heart disease (CHD) and depression. Methods The most common databases were chosen for data research, including PubMed, Web of Science, and EMBASE. We searched the data from the inception date through Mar. 16, 2023. The effect estimates and heterogeneity was synthesized by Review Manager version 5.3. Sensitivity analysis and publication bias were analyzed by STATA software. Results By searching the databases, we identified a total of 6750 articles. There were 22 articles left after selection, including 6344 participants. This meta-analysis indicates that CHD patients with depression have higher levels of CRP (0.45 [0.08, 0.82], P=0.02), hs-CRP (0.28 [0.07, 0.48], P=0.008) and a lower level of SDNN (-0.64 [-1.11, -0.17], P=0.008), SDANN (-12.77 [-21.20, -4.33], P=0.003), SDNNIDX (-13.83 [-15.94, -11.72], P<0.00001), RMSSD (-8.02 [-13.62, -2.43], P=0.005) pNN50 (-0.86 [-1.41, -0.31], P=0.002), than those without depression. Conclusion This study highlights that a higher level of inflammatory factors and lower HRV would help to predict depressive symptoms in CHD patients.

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Special Issue “C-Reactive Protein and Cardiovascular Disease: Clinical Aspects”

Abstract: This Special Issue focuses on the clinical relevance of C-reactive protein [...]

Cited by 2 publications

References 30 publications

Meta-analysis on inflammation and autonomic nervous system of coronary heart disease combined with depression

Meta-analysis on inflammation and autonomic nervous system of coronary heart disease combined with depression

A meta-analysis on inflammation and autonomic nervous system of coronary heart disease combined with depression

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