Special Issue: Application of Extracellular Matrix in Regenerative Medicine

Turner, Neill J.

doi:10.3390/app11073262

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…The ECM structure comprises of a variety of macromolecules such as fibrous proteins (collagen, fibronectin, vitronectin, elastin, and laminin), glycosaminoglycans, and proteoglycans [ 236 ]. The ECM plays a crucial role in directing the wound healing process by managing cell behavior (adhesion, migration, proliferation, and differentiation) and cellular activities in the damaged skin for tissue repair and regeneration [ 237 , 238 , 239 ]. In addition, the dynamic ECM structure acts as a reservoir for the storage and delivery of different growth factors and cytokines to provide biological signals.…”

Section: Innovative Strategies For Wound Healingmentioning

confidence: 99%

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Kolimi

Narala

Nyavanandi

et al. 2022

Cells

141

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Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and chronic state which is more susceptible to infections. Chronic wounds affect patients’ quality of life along with increased morbidity and mortality and are huge financial burden to healthcare systems worldwide, and thus requires specialized biomedical intensive treatment for its management. The clinical assessment and management of chronic wounds remains challenging despite the development of various therapeutic regimens owing to its painstakingly long-term treatment requirement and complex wound healing mechanism. Various conventional approaches such as cell therapy, gene therapy, growth factor delivery, wound dressings, and skin grafts etc., are being utilized for promoting wound healing in different types of wounds. However, all these abovementioned therapies are not satisfactory for all wound types, therefore, there is an urgent demand for the development of competitive therapies. Therefore, there is a pertinent requirement to develop newer and innovative treatment modalities for multipart therapeutic regimens for chronic wounds. Recent developments in advanced wound care technology includes nanotherapeutics, stem cells therapy, bioengineered skin grafts, and 3D bioprinting-based strategies for improving therapeutic outcomes with a focus on skin regeneration with minimal side effects. The main objective of this review is to provide an updated overview of progress in therapeutic options in chronic wounds healing and management over the years using next generation innovative approaches. Herein, we have discussed the skin function and anatomy, wounds and wound healing processes, followed by conventional treatment modalities for wound healing and skin regeneration. Furthermore, various emerging and innovative strategies for promoting quality wound healing such as nanotherapeutics, stem cells therapy, 3D bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based approaches, and cold plasma treatment therapy have been discussed with their benefits and shortcomings. Finally, challenges of these innovative strategies are reviewed with a note on future prospects.

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Section: Innovative Strategies For Wound Healingmentioning

confidence: 99%

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Kolimi

Narala

Nyavanandi

et al. 2022

Cells

141

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“…However the surface of the wings of cicada species has been demonstrated to possess bacteriostatic and bactericidal effects, which are attributed to nanoscale denticle structures with different densities and diameters on the cicada wings. Considering the tissues in a multicellular organism, nanotopography has also been found everywhere in the extracellular matrix (ECM) around cells 7 – 9 , which mainly consists of various fibrous proteins and proteoglycans 10 . For instance, parallelly aligned collagen fibrils approximately 50–200 nm in diameter make up the ECMs of the tendon and myocardium 11 , 12 , while the basement membranes of epithelia exhibit a complex texture with pits, bumps, grooves, and ridges in the nanometer range 13 , 14 .…”

Section: Introductionmentioning

confidence: 99%

Rapid nanomolding of nanotopography on flexible substrates to control muscle cell growth with enhanced maturation

Chin

Qing-yun

et al. 2021

Microsyst Nanoeng

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In vivo, multiple biophysical cues provided by highly ordered connective tissues of the extracellular matrix regulate skeletal muscle cells to align in parallel with one another. However, in routine in vitro cell culture environments, these key factors are often missing, which leads to changes in cell behavior. Here, we present a simple strategy for using optical media discs with nanogrooves and other polymer-based substrates nanomolded from the discs to directly culture muscle cells to study their response to the effect of biophysical cues such as nanotopography and substrate stiffness. We extend the range of study of biophysical cues for myoblasts by showing that they can sense ripple sizes as small as a 100 nm width and a 20 nm depth for myotube alignment, which has not been reported previously. The results revealed that nanotopography and substrate stiffness regulated myoblast proliferation and morphology independently, with nanotopographical cues showing a higher effect. These biophysical cues also worked synergistically, and their individual effects on cells were additive; i.e., by comparing cells grown on different polymer-based substrates (with and without nanogrooves), the cell proliferation rate could be reduced by as much as ~29%, and the elongation rate could be increased as much as ~116%. Moreover, during myogenesis, muscle cells actively responded to nanotopography and consistently showed increases in fusion and maturation indices of ~28% and ~21%, respectively. Finally, under electrical stimulation, the contraction amplitude of well-aligned myotubes was found to be almost 3 times greater than that for the cells on a smooth surface, regardless of the substrate stiffness.

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Combining Multiple Photosensitizer Modules into One Supramolecular System for Synergetic Enhanced Photodynamic Therapy

Li,

Zhang,

et al. 2024

Angewandte Chemie

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Photodynamic therapy (PDT) as an emerging cancer treatment requires the development of highly desirable photosensitizers (PSs) with integrated functional groups to achieve enhanced therapeutic efficacy. Coordination‐driven self‐assembly (CDSA) would provide an alternative approach for combining multiple PSs synergistically. Here, we demonstrate a simple yet powerful strategy of combining conventional chromophores (tetraphenylethylene, porphyrin, or Zn‐porphyrin) with pyridinium salts PSs together via condensation reactions, followed by CDSA to construct a series of novel metallo‐supramolecular PSs (S1–S3). The generation of reactive oxygen species (ROS) is dramatically enhanced via the direct combination of two different PSs, and further reinforced in the cases of the subsequent ensembles. Among all the ensembles, S2 with porphyrin core shows the highest ROS generation efficiency, specific interaction towards lysosome, and strong emission for probing cells. Moreover, the cellular and living experiments confirm that S2 owns excellent PDT efficacy, biocompatibility, and biosafety. As such, this work will shed light on the advancement of more efficient PSs with potential clinical applications.

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Special Issue: Application of Extracellular Matrix in Regenerative Medicine

Cited by 6 publications

References 7 publications

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Rapid nanomolding of nanotopography on flexible substrates to control muscle cell growth with enhanced maturation

Combining Multiple Photosensitizer Modules into One Supramolecular System for Synergetic Enhanced Photodynamic Therapy

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