Special Issue “APOBECs and Virus Restriction”

Chelico, Linda

doi:10.3390/v13081613

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…Some host genetic factors (genetic mutations) such as apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G) have been reported to affect the progression of HIV-1 infection and the chronicity of hepatitis B [10,11]. In fact, APOBEC3G (A3G) is a potent host genetic factor that has been widely reported to be associated with HIV and HBV infections [12,13]. In the absence of the HIV-1 virion infectivity factor (vif), A3G incorporates into newly synthesized viral particles and mutates, in HIV singlestranded DNA (ssDNA) from deoxycytidine (dC) to deoxyuridine (dU) during reverse transcription leading to a substitution of deoxyguanosine (dG) to deoxyadenosine (dA) in the plus-strand provirus DNA [14].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of HBsAg among Moroccan HIV-1 infected patients and APOBEC3G variant frequencies in HIV-1/HBV co-infection

Belbacha,

Bensghir,

Filali Marhoum

et al. 2024

J Infect Dev Ctries

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Introduction: Human immunodeficiency virus (HIV) / hepatitis B virus (HBV) causes higher rates of liver disease compared to infection with just one virus. Co-infection can accelerate the progression to liver fibrosis or hepatocellular carcinoma and disturb the treatment response. APOBEC3G is a host defense factor which interferes with HIV-1 and HBV. We aimed to determine the prevalence of hepatitis B surface antigen (HBsAg) among HIV-infected patients and seronegative controls, and screen the HIV/HBV population for APOBEC3G variants rs8177832, rs35228531 and rs2294367, previously associated with HIV-1 infection susceptibility in Morocco. Methodology: A case control study was conducted on 404 individuals (204 HIV-infected and 200 eligible blood donors) from April to November 2021. HBsAg was measured on the Roche Cobas e411 automatic analyzer (Roche Diagnostics, Basel, Switzerland) and APOBEC3G polymorphisms were identified using the TaqMan genotyping allelic discrimination method. Fisher Exact test, odds ratio (OR) with 95% confidence interval (CI), and haplotype frequencies were calculated. Results: Of the 204 HIV-1 seropositive patients and 200 controls, 4.9% (95%CI: 2.38-8.83) and 2.50% (95% CI: 0.82-5.74) were HBsAg-positive respectively. There was a significant association between increasing age (> 40 years) and HBV infection among controls (p = 0.04). The distribution of genotypes and alleles frequencies of APOBEC3G variants was heterogenous and five different haplotypes with frequencies ≥ 5% were obtained, of which ACC (rs8177832, rs35228531, rs2294367) was the most prevalent. Conclusions: HBV co-infection is common among HIV-1 infected individuals in Morocco. Efforts should be made to prevent, treat and control HBV transmission in this population.

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