Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin

Luo, Changyong; Li, Yan; Xu, Liang; Chen, Yifan; Zou, Qiao; Kong, Yurong; Guo, Zhengguang; Sun, Wei; Wang, Xin

doi:10.1080/21655979.2021.1969201

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…The protein-protein and protein-chemical interactions for RvD1 were determined using the STITCH ( http://stitch.embl.de/ ) search function [ 19 ]. Cytoscape software ( https://cytoscape.org/index.html ) was used to reconstruct and visualize the network [ 21 , 22 ] of RvD1-targeted genes and chemicals. Then, the RvD1-targeted genes and related KEGG pathways also were analyzed.…”

Section: Methodsmentioning

confidence: 99%

Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics

Jiang

Wang

et al. 2022

Bioengineered

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Osteoarthritis (OA) is a common chronic degenerative disease characterized by the loss of articular cartilage, which causes loss of joint function and reduce quality of life. Resolvin D1 (RvD1) has shown interesting anti-inflammatory effects; however, the mechanism of action of RvD1 in OA remains unclear. The aim of this study was to investigate the potential mechanism of RvD1 in OA by bioinformatics and partial in vitro mechanisms. Here, 106 shared differentially expressed genes (DEGs) were identified based on the GSE82107, GSE55235, GSE55457 dataset; 700 DEGs were identified based on GSE169077. Enrichment analyses of these genes were then successively conducted. RvD1-targeted genes and KEGG pathways are identified by STITCH. 27 shared KEGG pathways were identified among RvD1-targeted pathways and OA. Furthermore, cell apoptosis assay, western blotting, real-time fluorescent quantitative PCR (qRT-PCR), enzyme linked immunosorbent assay (ELISA) were used to confirm the expression levels of the key genes of shared Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways between RvD1-targeted and OA in IL-1β treated rat knee chondrocytes. The results showed that RvD1-targeted pathways and the expression of nuclear p65, p53, and p-JNK were inhibited in the RvD1 group compared with the IL-1β group. Thus, the findings indicate that RvD1 may inhibit the development of OA through NF/kB, p53, MAPK/JNK, PI3K-AKT signaling pathways, and act as a treatment for OA.

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Section: Methodsmentioning

confidence: 99%

Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics

Jiang

Wang

et al. 2022

Bioengineered

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Far-infrared radiation and its therapeutic parameters: A superior alternative for future regenerative medicine?

Qin,

Fu,

et al. 2024

Pharmacological Research

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Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin

Abstract: 2021) Special electromagnetic field-treated water and farinfrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin,

Cited by 2 publications

References 32 publications

Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics

Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics

Far-infrared radiation and its therapeutic parameters: A superior alternative for future regenerative medicine?

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