We prove the rationality of some Fano fourfolds via Mori Theory and the Minimal Model Program. The method shows a connection between some admissible cubic fourfolds and some birational models of their associated K3 surfaces, pointing out that in these cases rationality may be closely related to the construction of special projections of the associated K3 surfaces. We provide several applications of our method among which we distinguish the solution of the Kuznetsov Conjecture for d = 42 (the first open case) and new proofs for d = 14, 26 and 38. A lot of relevant examples are included, opening the way to further applications of this circle of ideas to the rationality of other classes of Fano fourfolds.