Special Article: The Study of Treatment for Renal Insufficiency: Data and Evaluation (STRIDE), a National Registry of Chronic Kidney Disease

Madhumathi, R; Kausz, Annamaria T.; Mitchell, Donald G.; Ratican, Sari Heller; Lin, Francie; Port, F. K.; Pereira, Brian J.G.

doi:10.1046/j.1525-139x.2002.00088.x

Cited by 13 publications

(5 citation statements)

References 18 publications

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“…Exclusion criteria were chronic dialysis at the time of enrollment, having received or being scheduled for a kidney transplant, anemia from causes other than kidney disease, or malignancy. Further study description has been published [11]. …”

Section: Methodsmentioning

confidence: 99%

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort

et al. 2015

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Background: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. Methods: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na⁺) and clinical outcomes. Results: Baseline estimated glomerular filtration rate (eGFR) and Na⁺ were 26 ± 11 ml/min/1.73 m² and 140.2 ± 3.4 mEq/l, respectively. The prevalence of Na⁺ ≤135 mEq/l and ≥144 mEq/l was 6 and 16%, respectively. Higher baseline Na⁺ was significantly associated with male sex, older age, systolic blood pressure, BMI, serum albumin, presence of heart failure, and lower eGFR. The risk of end-stage renal disease (ESRD) was marginally significantly higher among patients with Na⁺ ≤135 mEq/l, compared with 140< Na⁺ <144 mEq/l (referent), in time-dependent models (adjusted hazard ratio, HR = 1.52, p = 0.06). Mortality risk was significantly greater at 135< Na⁺ ≤140 mEq/l (adjusted HR = 1.68, p = 0.02) and Na⁺ ≥144 mEq/l (adjusted HR = 2.01, p = 0.01). Conclusion: CKD patients with Na⁺ ≤135 mEq/l were at a higher risk for progression to ESRD, whereas both lower and higher Na⁺ levels were associated with a higher risk of mortality. While caring for CKD patients, greater attention to serum sodium levels by clinicians is warranted and could potentially help improve patient outcomes.

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Section: Methodsmentioning

confidence: 99%

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort

et al. 2015

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“…Two ongoing prospective, observational studies measured detailed clinical characteristics at baseline and continue to follow patients to predict a range of outcomes, including ESRD[6,7]. Both CRIC and STRIDE enrolled patients with known CKD who were identified in the clinic-based setting.…”

Section: Introductionmentioning

confidence: 99%

Predicting the risk of end-stage renal disease in the population-based setting: a retrospective case-control study

et al. 2011

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BackgroundPrevious studies of predictors of end-stage renal disease (ESRD) have limitations: (1) some focused on patients with clinically recognized chronic kidney disease (CKD); (2) others identified population-based patients who developed ESRD, but lacked earlier baseline clinical measures to predict ESRD. Our study was designed to address these limitations and to identify the strength and precision of characteristics that might predict ESRD pragmatically for decision-makers--as measured by the onset of renal replacement therapy (RRT).MethodsWe conducted a population-based, retrospective case-control study of patients who developed ESRD and started RRT. We conducted the study in a health maintenance organization, Kaiser Permanente Northwest (KPNW). The case-control study was nested within the adult population of KPNW members who were enrolled during 1999, the baseline period. Cases and their matched controls were identified from January 2000 through December 2004. We evaluated baseline clinical characteristics measured during routine care by calculating the adjusted odds ratios and their 95% confidence intervals after controlling for matching characteristics: age, sex, and year.ResultsThe rate of RRT in the cohort from which we sampled was 58 per 100,000 person-years (95% CI, 53 to 64). After excluding patients with missing data, we analyzed 350 cases and 2,114 controls. We identified the following characteristics that predicted ESRD with odds ratios ≥ 2.0: eGFR<60 mL/min/1.73 m2 (OR = 20.5; 95% CI, 11.2 to 37.3), positive test for proteinuria (OR = 5.0; 95% CI, 3.5 to 7.1), hypertension (OR = 4.5; 95% CI, 2.5 to 8.0), gout/positive test for uric acid (OR = 2.5; 95% CI, 1.8 to 3.5), peripheral vascular disease (OR = 2.2; 95% CI, 1.4 to 3.6), congestive heart failure (OR = 2.1; 95% CI, 1.4 to 3.3), and diabetes (OR = 2.1; 95% CI, 1.5 to 2.9).ConclusionsThe clinical characteristics needed to predict ESRD--for example, to develop a population-based, prognostic risk score--were often documented during routine care years before patients developed ESRD and required RRT.

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“…The LCKD Study along with the STRIDE Registry (12) and the more recently initiated NIH sponsored CRIC Study (31) will provide rich epidemiological insight into various aspects of CKD. These ongoing studies are testimony to the high priority the renal community places on the study of CKD prior to the initiation of the renal replacement therapy.…”

Section: Resultsmentioning

confidence: 99%

“…The University of Michigan is the data coordinating center, and all statistical analyses are being carried out at the Kidney Epidemiology and Cost Center, Ann Arbor, MI. In October 2000, data from the LCKD study were linked to the Study of Treatment for Renal Insufficiency: Data and Evaluation (STRIDE) Registry (12) in order to extend this observational study to a number of nephrology practices around the country. Data collection instruments for the two studies are identical with the exception of QOL data collection methods.…”

Section: Study Methodsmentioning

confidence: 99%

“…Similarly, although certain interventions such as blood pressure and glycemic control are widely accepted, other factors or practice patterns associated with slower progression of disease and improved quality of life (QOL) remain to be better defined. Research looking at CKD and improving management prior to the initiation of dialysis is therefore receiving the attention it deserves both in the United States and elsewhere (12–14).…”

Section: Introductionmentioning

confidence: 99%

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RENAL RESEARCH INSTITUTE SYMPOSIUM: The Longitudinal Chronic Kidney Disease Study: A Prospective Cohort Study of Predialysis Renal Failure

Perlman

Kiser

Finkelstein

et al. 2003

Seminars in Dialysis

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Chronic kidney disease (CKD) is a significant public health problem: every year the number of Americans living with CKD and requiring renal replacement therapy increases. In addition, individuals with CKD have substantially increased morbidity and mortality compared to the general population. The Longitudinal Chronic Kidney Dialysis (LCKD) Study is a multicenter, prospective, observational study of patients with moderate to severe CKD that was designed to better describe the course of the disease and the determinants of patient outcomes. Patients with moderate to severe CKD (glomerular filtration rate [GFR] < 60 ml/min/m2) from four academic nephrology clinics were enrolled between 2000 and 2002. Special cardiac and vascular testing has recently commenced as phase II of this study. Areas that have been or are currently being studied include anemia management, health-related quality of life (HRQOL), medication use, and markers of cardiovascular disease. This article describes the LCKD Study in the context of current knowledge of CKD.

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Special Article: The Study of Treatment for Renal Insufficiency: Data and Evaluation (STRIDE), a National Registry of Chronic Kidney Disease

Cited by 13 publications

References 18 publications

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort

Predicting the risk of end-stage renal disease in the population-based setting: a retrospective case-control study

RENAL RESEARCH INSTITUTE SYMPOSIUM: The Longitudinal Chronic Kidney Disease Study: A Prospective Cohort Study of Predialysis Renal Failure

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