Special Article

Hurst, Daniel J.; Hurst, Mary Jane

doi:10.1097/00002826-198409000-00007

Cited by 4 publications

(1 citation statement)

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“…These two sets of studies [41,85] appear to be mutually consistent, although it would have been helpful had the latter set been carried to longer times. This pH behavior underscores the profound differences in macrophage and neutrophil activation, the phagosome of the latter having been shown in several studies to undergo initial alkanization on the time scale of microbial killing, followed by slow acidification to pH ~6 [88–90]. In any event, it appears that mechanisms of killing by H 2 O 2 and NO 2 − occurring in vitro in acidic media are not expressed within either of these phagocytes because the requisite levels of acidification (pH 5) are not achievedon the respective microbicidal time scales.…”

Section: Nitrite Involvement In Macrophage Reactionsmentioning

confidence: 79%

The role of nitrite ion in phagocyte function—perspectives and puzzles

Cape

Hurst

2009

Archives of Biochemistry and Biophysics

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Macrophages and neutrophils are essential elements of host cellular defense systems that function, at least in part, by generating respiration-driven oxidative toxins in response to external stimuli. In both cells, encapsulation by phagocytosis provides a mechanism to direct the toxins against the microbes. The toxic chemicals formed by these two phagocytic cells differ markedly, as do the enzymatic catalysts that generate them. Nitrite ion is microbicidal under certain conditions, is generated by activated macrophages, and is present at elevated concentration levels at infection sites. In this review, we consider potential roles that nitrite might play in cellular disinfection by these phagocytes within the context of available experimental information. Although the suggested roles are plausible, based upon the chemical and biochemical reactivity of NO2−, studies to date provide little support for their implementation within phagosomes.

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Section: Nitrite Involvement In Macrophage Reactionsmentioning

confidence: 79%