SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin

The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo

“…Knockout of the canonical MLCP regulatory subunit MYPT1 causes death during embryonic development ( 25 ). MYPT1 is ubiquitously expressed and implicated in the determination of cell polarity in cytokinesis ( 26 ), regulation of cell growth through YAP-mediated signaling ( 27 ), and cell motility ( 28 ). MYPT2 has 87% sequence homology with MYPT1, with conservation of all major structural domains.…”