Abstract:The subcellular localization, activity and substrate specificity of the serine/threonine protein phosphatase 1 catalytic subunit (PP1 cat) is mediated through its dynamic association with regulatory subunits in holoenzyme complexes. While some functional overlap is observed for the three human PP1cat isoforms, they also show distinct targeting based on relative preferences for specific regulatory subunits. A well-known example is the preferential association of MYPT1 with PP1β in the myosin phosphatase comple… Show more
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