SPE-UHPLC-ESI-MS/MS Analysis of Cocaine and Its Metabolites in Conventional and Alternative Biological Specimens: Application to Real Samples
Humera Shafi Makhdoom,
Saira Afzal,
Kishwar Sultana
et al.
Abstract:An increase in cocaine
abuse has been observed globally since the past decade. Cocaine is
among the commonly abused stimulants used for recreational purposes.
In this study, the SPE-UHPLC-MS/MS method was developed and validated
to be applied on real specimens of 20 chronic cocaine abusers to quantify
cocaine/metabolites in conventional as well as alternative biological
matrices. Cocaine was extracted from biological specimens using solid-phase
extraction followed by liquid chromatography tandem mass spectrome… Show more
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