SPE of Tanshinones from Salvia miltiorrhiza Bunge by using Imprinted Functionalized Ionic Liquid-Modified Silica

Abstract

Ionic liquid-modified silica, with functional groups based on imidazole as the cation, was obtained. A molecular imprinting technique was introduced to form the order of functional groups. The selectivity of the obtained ionic liquid-modified silica was successfully used as a special imprinted sorbent in the solid-phase extraction to isolate cryptotanshinone, tanshinone I and tanshinone IIA from Salvia miltiorrhiza Bunge. Several washing and elution solvents with different polarities were evaluated. The ionic liquid-modified silica as the sorbent exhibited a higher selectivity than blank ionic liquid-modified silica, traditional silica and C 18 cartridges. A quantitative analysis was conducted by liquid chromatography with a C 18 column and methanol/water (75:25, v/v, containing 0.5% acetic acid) as the mobile phase. A good linearity was obtained from 0.5 9 10 -4 to 0.1 mg mL -1 (r 2 [ 0.99) with relative standard deviations that were less than 4.6%.

Application of ionic liquid for extraction and separation of bioactive compounds from plants

“…N-Hexylimidazoliam tetrafluoroborate based silica [163] Imidazolium chloride based silica [164] 2-ethyl-4-methylimidazole chloride based silica [165,166] N-Methylimidazole chloride based silica N-(Propyl-3-amino)imidazolium bromide based silica [170,171] Pridinium chloride based silica [172] N-Butylimidazolium bromide based silica N-(butyl-4-sulfonate) imidazolium trifluoromethanesulfonate based silica [173] N-Butylimidazolium bromide based silica [174] N-(Propyl-3-sufonate) imidazolium chloride based silica [175] functional monomer, and methacryloxypropyltrimethoxysilane (MPTMS), which acts as a crosslinker. As a carboxylic acid, MAA catalyzes the non-hydrolytic sol-gel condensation of MPTMS, and the Si-O-Si framework is formed according to Green et al's work [177].…”

Recent advances and future trends in new materials for sample preparation

“…Tian et al [53] used IL-based silica containing an imidazolium cation to isolate analytes from complex matrices. Comparison between an IL-based silica sorbent and traditional silica sorbents in SPE for the isolation of cryptotanshinone, tanshinone I and tanshinone IIA from Salvia Miltiorrhiza Bunge [53] showed higher recoveries when IL-based silica sorbents were used. Today, there are still few reports on the use of IL-based silica SPE sorbents for sample preparation in environmental, water, food, soil and biological samples.…”

“…In several cases, IL-based silica cartridges showed higher selectivity or higher recovery than those obtained utilizing commercially-available cartridges. The ILs most used for IL-based silica were imidazolium [53,[55][56][57], N-methylimidazolium [54] and 2-ethyl-4-methylimidazolium [58] as organic cation and chloride [53,55,58] or hexafluorophosphate [54,[59][60][61] as anion.…”

Fabrication of core–shell structured magnetic nanocellulose base polymeric ionic liquid for effective biosorption of Congo red dye

“…They are mainly characterized as a green reaction media possessing low melting points, negligible vapor pressures, and high thermal stability (López-Darias et al, 2011;Tian and Row, 2011) but they suffers from low feasibility of recycling. Immobilization of ionic liquids on a solid matrix can resolve this serious drawback.…”