SPATS2 is positively activated by long noncoding RNA SNHG5 via regulating DNMT3a expression to promote hepatocellular carcinoma progression

Jia, Yan; Huang, Qing; Huang, Ya Jun; Wang, Chang Shan; Liu, Peng Xia

doi:10.1371/journal.pone.0262262

Cited by 5 publications

(2 citation statements)

References 22 publications

(25 reference statements)

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“…Li et al discovered that SNHG5 contributed to the proliferation and migration of hepatocellular carcinoma (HCC) cells through regulating GSK3β and the Wnt/β-catenin signalling pathway by competitively binding miR-26a-5p [ 33 ]. Yan et al suggested that SNHG5 could promote the proliferation and migration of HCC cells by upregulating spermatogenesis-associated serine-rich 2 ( SPATS2) expression ( 47 ). Zhang et al indicated that SNHG5 accelerates the proliferation, migration and invasion of cervical cancer cells through upregulating sex-determining region Y-Box 4 ( SOX4 ) expression via competitive sponging of miR-132 [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

An increase in SNHG5 expression is associated with poor cancer prognosis, according to a meta-analysis

Huang,

Xia,

Huang

et al. 2024

Eur J Med Res

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Background He long noncoding RNA small nucleolar host RNA 5 (SNHG5) is highly expressed in many cancers, and there is a notable correlation between the elevated expression of SNHG5 and survival outcome in cancer patients. The objective of this study was to conduct a meta-analysis to evaluate the correlation between SNHG5 expression and the clinical outcome of cancer patients. Methods Six relevant electronic databases were exhaustively searched, and, depending on the inclusion and exclusion criteria, appropriate literature was obtained. The Newcastle-Ottawa Scale (NOS) score was utilized to evaluate the quality of the research for every article included, and pertinent data from each study were carefully extracted. Hazard ratios (HRs), odds ratios (ORs) and 95% confidence intervals (CIs) were combined to explore the association of SNHG5 expression levels with cancer prognosis, and sensitivity analyses and assessments of publication bias were also conducted to investigate any possibility in the publication of the studies. Results Eleven studies encompassing 721 patients were ultimately collected. When combined, the hazard ratios (HRs) revealed a substantial direct correlation between elevated SNHG5 expression and an unfavourable prognosis for cancer patients (HR = 1.90, 95% CI 0.87–4.15); however, the correlation did not reach statistical significance. Furthermore, high SNHG5 expression was predictive of advanced TNM stage (OR: 1.988, 95% CI 1.205–3.278) and larger tumour size (OR: 1.571, 95% CI 1.090–2.264); moreover, there were nonsignificant relationships between SNHG5 expression and DM (OR: 0.449, 95% CI 0.077–2.630), lymph node metastasis (OR: 1.443, 95% CI 0.709–2.939), histological grade (OR: 2.098, 95% CI 0.910–4.838), depth of invasion (OR: 1.106, 95% CI 0.376–3.248), age (OR: 0.946, 95% CI 0.718–1.247) and sex (OR: 0.762, 95% CI 0.521–1.115). Conclusion SNHG5 expression is typically increased in the majority of tumour tissues. Elevated SNHG5 expression may indicate poor prognosis in cancer patients. Therefore, SNHG5 is a promising potential therapeutic target for tumours and a reliable prognostic biomarker.

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Section: Discussionmentioning

confidence: 99%

An increase in SNHG5 expression is associated with poor cancer prognosis, according to a meta-analysis

Huang,

Xia,

Huang

et al. 2024

Eur J Med Res

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“…[11][12][13] Several lncRNAs have been identified to serve as the prognostic indicators for HCC, such as TUG1, [12] LINC01234, [11] and SNHG5. [14] Recently, homeobox transcript antisense intergenic RNA (HOTAIR), a lncRNA, has been verified to be associated with the prognosis of HCC. [13,[15][16][17][18][19][20][21][22] Han et al study showed high HOTAIR expression was an independent prognostic factor of overall survival (OS) (P < .01) and progression-free survival (PFS) (P < .01) in patients with advanced HCC treated by sunitinib.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of long noncoding RNA HOTAIR in hepatocellular carcinoma: A protocol for systematic review and meta-analysis

Feng

Liu

et al. 2022

Medicine

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Background: Homeobox transcript antisense intergenic RNA (HOTAIR), a long noncoding RNA, has been reported to associate with the prognosis of patients with hepatocellular carcinoma (HCC) in several studies, however, the definite conclusion has not been obtained for conflicting results across different studies. The aim of this study is to determine the association of HOTAIR expression with overall survival, progression-free survival, and clinical features in HCC.Methods: PubMed, Cochrane Library, and Embase will be comprehensively searched to seek the relevant studies. The studies meeting the inclusion criteria will be included into this systematic review and meta-analysis. A combination of hazard ratio and 95% confidence interval is used to estimate the impact of HOTAIR expression on the overall survival and progression-free survival in HCC. The relationship between HOTAIR expression and clinical features of HCC is evaluated using the odds ratio and 95% confidence interval. The study quality is evaluated with the "risk of bias assessment" tool in Cochrane System Assessment Manual or Newcastle-Ottawa Scale. The subgroup analysis, publication bias, and sensitivity analysis are performed.Results: This study provides a strict and classic protocol for systematic review and meta-analysis to determine the prognostic significance of HOTAIR expression in HCC. The findings of this systematic review and meta-analysis may provide a novel diagnostic indicator and potential therapeutic target of HCC.Ethics and dissemination: This study is only a protocol for systematic review and meta-analysis, and all data used in this study is acquired through published studies. Therefore, the ethical review is not needed for this study.

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Prognostic model based on B cell marker genes for NSCLC patients under neoadjuvant immunotherapy by integrated analysis of single-cell and bulk RNA-sequencing data

Liu,

Bie,

Bai

et al. 2024

Clin Transl Oncol

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SPATS2 is positively activated by long noncoding RNA SNHG5 via regulating DNMT3a expression to promote hepatocellular carcinoma progression

Cited by 5 publications

References 22 publications

An increase in SNHG5 expression is associated with poor cancer prognosis, according to a meta-analysis

An increase in SNHG5 expression is associated with poor cancer prognosis, according to a meta-analysis

Prognostic significance of long noncoding RNA HOTAIR in hepatocellular carcinoma: A protocol for systematic review and meta-analysis

Prognostic model based on B cell marker genes for NSCLC patients under neoadjuvant immunotherapy by integrated analysis of single-cell and bulk RNA-sequencing data

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