Spatiotemporally Controlled Photolabeling of Genetically Unmodified Proteins in Live Cells
Huaibin Yu,
Shuangshuang Wang,
Yu Fu
et al.
Abstract:Selective labeling of the protein of interest (POI) in genetically unmodified live cells is crucial for understanding protein functions and kinetics in their natural habitat. In particular, spatiotemporally controlled installation of the labels on a POI under light control without affecting their original activity is in high demand but is a tremendous challenge. Here, we describe a novel ligand-directed photoclick strategy for spatiotemporally controlled labeling of endogenous proteins in live cells. It was re… Show more
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