Spatiotemporal switching signals for cancer stem cell activation in pediatric origins of adulthood cancer: Towards a watch-and-wait lifetime strategy for cancer treatment

Abstract

Pediatric origin of cancer stem cell hypothesis holds great promise and potential in adult cancer treatment, however; the road to innovation is full of obstacles as there are plenty of questions left unanswered. First, the key question is to characterize the nature of such stem cells (concept). Second, the quantitative imaging of pediatric stem cells should be implemented (technology). Conceptually, pediatric stem cell origins of adult cancer are based on the notion that plasticity in early life developmental programming evolves local environments to cancer. Technologically, such imaging in children is lacking as all imaging is designed for adult patients. We postulate that the need for quantitative imaging to measure space-time changes of plasticity in early life developmental programming in children may trigger research and development of the imaging technology. Such quantitative imaging of pediatric origin of adulthood cancer will help develop a spatiotemporal monitoring system to determine cancer initiation and progression. Clinical validation of such speculative hypothesis-that cancer originates in a pediatric environment-will help implement a wait-and-watch strategy for cancer treatment.

Breathing Signature as Vitality Score Index Created by Exercises of Qigong: Implications of Artificial Intelligence Tools Used in Traditional Chinese Medicine

“…As a test of this concept, we propose to implement a cross-institutional prospective study that uses Qigong breathing exercise as an integrated point of health assessment and appropriate combination therapies to associate the "breathing signature" with immune system biomarkers [57], thereby defining a vitality score index (VSI), an indication that can be daily monitored. Such an association study would establish a tracking pattern [58] to allow the definition of a "therapeutic window" [31] for a spatiotemporal assessment [59] to direct long-term care strategy. However, the breakthrough will come from establishing an AI-Medicine training camp of databases, which will integrate the connection of Qigong-like breathing patterns with individual pathology.…”

Cancer Niche as a Garbage Disposal Machine: Implications of TCM-Mediated Balance of Body- Disease for Treatment of Cancer

“…Cocktail drugs for Signaling pathways. Immunotherapy (Li S, et al [8]), Cancer genome (Li SC, et al [14]), Precision oncology, single-cell approach of cancer (Li SC, et al [5,6]), cancer subclonal evolution landscape (ILi SC, et al [15]), CRISPR–Cas9-based genome editing of cancer treatment, stem cell therapy of cancer (Li SC, et al [16]), Moon-shot of cancer, and Artificial Intelligence of Medicine (AI Medicine), just to name a few. The following examples illustrate that some of these strategies did not prevail over cancer heterogeneity and complexity.…”

“…Such quantitative imaging of pediatric origin of adulthood cancer will help develop a spatiotemporal monitoring system to determine cancer initiation and progression. Clinical validation of such speculative hypothesis-that cancer originates in a pediatric environment-will help implement a wait-and-watch strategy for cancer treatment” [5,6].…”

“…Borrowing from the metaphor above, researchers came up with a concept of spatiotemporal switching control of cancer with TME as an ecosystem [5,6]. Some examples can be used to illustrate such control switching mechanism.…”

“…One of the bottlenecks is to prevent the distant metastasis of cancer that causes an increasing number of cancer-related deaths. However, the potential mechanisms of metastasis and candidate biomarkers are still to be elucidated, although multiple models have been established, but with despaired results [5,6].…”