Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system

Ohta, Yoshikuni; Itoh, Kyoko; Yaoi, Takeshi; Tando, So; Fukui, Kenji; Fushiki, Shinji

doi:10.1016/j.devbrainres.2005.01.001

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…We here provide an analysis of SynCAM 1–4 expression at postnatal and adult stages that complements and extends previous and more general immunohistochemical studies (Biederer et al, 2002; Ohta et al, 2005) that utilized pleio-SynCAM antibodies recognizing SynCAM 1, 2, and 3 equally well (Fogel et al, 2007). Divergent SynCAM transcript expression is detected in all analyzed forebrain regions.…”

Section: Discussionsupporting

confidence: 57%

Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions

Thomas

Akins

Biederer

2008

J of Comparative Neurology

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Cell-cell interactions through adhesion molecules play key roles in the development of the nervous system. SynCAMs (Synaptic Cell Adhesion Molecules) comprise a group of four immunoglobulin (Ig) superfamily members that mediate adhesion and are prominently expressed in the brain. Although SynCAMs have been implicated in the differentiation of neurons, there has been no comprehensive analysis of their expression patterns. We here examine the spatiotemporal expression patterns of SynCAMs using RT-PCR, in situ hybridization, and immunohistological techniques. SynCAMs 1–4 are widely expressed throughout the developing and adult central nervous system. They are prominently expressed in neurons throughout the brain and present in both excitatory and inhibitory neurons. Investigation of different brain regions in the developing and mature mouse brain indicates that each SynCAM exhibits a distinct spatiotemporal expression pattern. This is observed in all regions analyzed and particularly notable in the cerebellum, where SynCAMs display highly distinct expression in cerebellar granule and Purkinje cells. These unique expression profiles are complemented by specific heterophilic adhesion patterns of SynCAM family members as shown by cell overlay experiments. Three prominent interactions are observed, mediated by the extracellular domains of SynCAMs 1/2, 2/4, and 3/4. These expression and adhesion profiles of SynCAMs together with their previously reported functions in synapse organization indicate that SynCAM proteins contribute importantly to the synaptic circuitry of the central nervous system.

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Section: Discussionsupporting

confidence: 57%

Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions

Thomas

Akins

Biederer

2008

J of Comparative Neurology

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“…1c). Altogether, these results show that members of the Necl gene family are differentially expressed by neurons and myelinating Schwann cells in peripheral nerves -sensory and motor neurons express Necl1 and Necl2 25,31,32 , whereas myelinating Schwann cells mainly express Necl4.…”

Section: Necl Proteins In the Peripheral Nervous Systemmentioning

confidence: 73%

A central role for Necl4 (SynCAM4) in Schwann cell–axon interaction and myelination

et al. 2007

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Myelination in the peripheral nervous system requires close contact between Schwann cells and the axon, but the underlying molecular basis remains largely unknown. Here we show that cell adhesion molecules (CAMs) of the Nectin-like (Necl, also known as SynCAM or Cadm) family mediate Schwann cell-axon interaction during myelination. Necl4 is the main Necl expressed by myelinating Schwann cells and is located along the internodes in direct apposition to Necl1, which is localized on axons. Necl4 serves as the glial binding partner for axonal Necl1, and the interaction between these two CAMs mediates Schwann cell adhesion. Furthermore, the disruption of the interaction between Necl1 and Necl4 by their soluble extracellular domains, as well as the expression of a dominant negative Necl4 in Schwann cells, inhibits myelination. These results suggest a critical role for Necl proteins in mediating axon-glia contact during myelination in peripheral nerves.

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“…Extensive analyses have revealed that Cadm1 is expressed during early development in rodents (Fujita et al, 2005;Ohta et al, 2005). It has been found in most epithelia and neuroepithelia, such as hair follicles, lung, liver, gut, tongue, olfactory epithelium, dorsal root ganglia, various regions of the central nervous system, being particularly enriched in the marginal zone of the cortex, the external granule layer of the cerebellum, the habenular nucleus, and the thalamus (Fujita et al, 2005;Ohta et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…It has been found in most epithelia and neuroepithelia, such as hair follicles, lung, liver, gut, tongue, olfactory epithelium, dorsal root ganglia, various regions of the central nervous system, being particularly enriched in the marginal zone of the cortex, the external granule layer of the cerebellum, the habenular nucleus, and the thalamus (Fujita et al, 2005;Ohta et al, 2005). Additionally, Cadm1 has been shown to be highly expressed in the testis during germ cell development.…”

Section: Introductionmentioning

confidence: 99%

Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish

Pietri

Easley-Neal

Wilson

et al. 2007

Developmental Dynamics

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The Cadm (cell adhesion molecule) family of cell adhesion molecules (also known as IGSF4, SynCAM, Necl and TSLC) has been implicated in a multitude of physiological and pathological processes, such as spermatogenesis, synapse formation and lung cancer. The precise mechanisms by which these adhesion molecules mediate these diverse functions remain unknown. To investigate mechanisms of action of these molecules during development, we have identified zebrafish orthologs of Cadm family members and have examined their expression patterns during development and in the adult. Zebrafish possess six cadm genes. Sequence comparisons and phylogenetic analysis suggest that four of the zebrafish cadm genes represent duplicates of two tetrapod Cadm genes, whereas the other two cadm genes are single orthologs of tetrapod Cadm genes. All six zebrafish cadms are expressed throughout the nervous system both during development and in the adult. The spatial and temporal patterns of expression suggest multiple roles for Cadms during nervous system development. Developmental Dynamics 237:233-246, 2008.

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Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system

Cited by 13 publications

References 25 publications

Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions

Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions

A central role for Necl4 (SynCAM4) in Schwann cell–axon interaction and myelination

Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish

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