Spatiotemporal Modulated Scaffold for Endogenous Bone Regeneration via Harnessing Sequentially Released Guiding Signals

Wang, Xinyu; Dai, Wenli; Gao, Chenyuan; Zhang, Liwen; Wan, Zhuo; Zhang, Tianyun; Wang, Yue; Tang, Yujing; Yu, Yingjie; Yang, Xiaoping; Cai, Qing

doi:10.1021/acsami.3c13963

Cited by 11 publications

(1 citation statement)

References 59 publications

(101 reference statements)

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“…As a new biocompatible and biodegradable metallic material, magnesium has attracted considerable attention in bone regeneration. − Compared with traditional titanium implants, magnesium possesses superior osteoinductive and immunomodulatory properties. Both cellular and animal experiments have proved strong osteogenic promotion of magnesium-based biomaterials .…”

Section: Introductionmentioning

confidence: 99%

Mg-Cross-Linked Alginate Hydrogel Induces BMSC/Macrophage Crosstalk to Enhance Bone Tissue Regeneration via Dual Promotion of the Ligand–Receptor Pairing of the OSM/miR-370-3p-gp130 Signaling Pathway

Gu,

Huang,

et al. 2024

ACS Appl. Mater. Interfaces

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Section: Introductionmentioning

confidence: 99%

Mg-Cross-Linked Alginate Hydrogel Induces BMSC/Macrophage Crosstalk to Enhance Bone Tissue Regeneration via Dual Promotion of the Ligand–Receptor Pairing of the OSM/miR-370-3p-gp130 Signaling Pathway

Gu,

Huang,

et al. 2024

ACS Appl. Mater. Interfaces

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Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration

Wang,

Pang

et al. 2024

Adv Funct Materials

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Native bone inherently requires a balanced ionic microenvironment to maintain bone homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into bone defects hold great promise for bone regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in the process of bone regeneration, impacting immunomodulation, angiogenesis, and osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres are developed as injectable microscaffolds (denoted as GMN). GMN enables sustained release of Mg/Si ions at an optimized ratio, achieving the most significant synergistic effect on vascularized bone regeneration. Various conditioned media are obtained to explore angiogenesis‐osteogenesis coupling, as well as the crosstalk between bone marrow mesenchymal stromal cells (BMSCs) and macrophages. Meanwhile, autocrine and paracrine effects simultaneously play synergistic modulating functions in determining cell fates under the guidance of Mg/Si ions and biofactors secreted by cells. Overall, the Mg/Si ion‐engineering microscaffolds create a conducive microenvironment to efficiently augment the regeneration of vascularized bone tissue in vivo, offering a versatile platform for tissue engineering.

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An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

Zhao,

Li,

Wang

et al. 2024

Adv Healthcare Materials

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Magnesium phosphate bone cement (MPC) has gained widespread usage in orthopedic implantation due to its fast‐setting and high initial strength benefits. However, the simultaneous attainment of drug‐controlled release and osteogenic potential in MPC remains a significant challenge. Herein, we proposed a strategy to create a smart injectable cement system using nanocontainers and chondroitin sulfate. It employed nanocontainers containing alendronate‐loaded mesoporous silica nanoparticles, which had been surface‐modified with polypyrrole to control drug release in response to near infrared (NIR) stimulation. The alendronate‐incorporated cement (ACMPC) exhibited improved compressive strength (70.6 ± 5.9 MPa), prolonged setting time (913 s), and exceptional injectability (96.5% of injection rate and 242 s of injection time). It also showed the capability to prevent degradation, thus preserving mechanical properties. Under NIR irradiation, the cement showed good antibacterial properties due to the combined impact of hyperthermia, reactive oxygen species, and alendronate. Furthermore, ACMPC (NIR) group displayed good biocompatibility and osteogenesis capabilities, which also led to an increase in alkaline phosphatase activity, extracellular matrix mineralization, and the upregulation of osteogenic genes. This research has significant implications for developing multifunctional biomaterials and clinical application.This article is protected by copyright. All rights reserved

show abstract

Spatiotemporal Modulated Scaffold for Endogenous Bone Regeneration via Harnessing Sequentially Released Guiding Signals

Cited by 11 publications

References 59 publications

Mg-Cross-Linked Alginate Hydrogel Induces BMSC/Macrophage Crosstalk to Enhance Bone Tissue Regeneration via Dual Promotion of the Ligand–Receptor Pairing of the OSM/miR-370-3p-gp130 Signaling Pathway

Mg-Cross-Linked Alginate Hydrogel Induces BMSC/Macrophage Crosstalk to Enhance Bone Tissue Regeneration via Dual Promotion of the Ligand–Receptor Pairing of the OSM/miR-370-3p-gp130 Signaling Pathway

Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration

An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

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