Spatiotemporal Lineshape Tailoring in BIC‐Mediated Reconfigurable Metamaterials (Adv. Funct. Mater. 34/2022)

Hu, Yuze; Tong, Mingyu; Hu, Siyang; He, Weibao; Cheng, Xina; Jiang, Tao

doi:10.1002/adfm.202270194

Cited by 15 publications

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“…[ 77 ] As a result of the rapid growth of cancerous cells and the abnormal formation of the tumor vascular system, the oxygen concentration of the TME (0–3% O 2 ) is relatively lower than that of normal tissue (5%–20% O 2 ). [ 10 ] Hypoxia‐responsive drug carriers have been developed for phototherapy to exploit this unique feature of tumors. For instance, because hypoxia leads to overexpression of reductases (e.g., azo reductase and nitro reductase), [ 78 ] a recent study incorporated an azobenzene group (AZO), an azo reductase‐sensitive moiety, into the structure of a covalent organic framework (COF) to achieve stimuli‐responsive disassembly.…”

Section: Tme‐induced Targeted Delivery Of Phototherapeuticsmentioning

confidence: 99%

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Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Jia

Feng

et al. 2023

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Canonical phototherapeutics have several limitations, including a lack of tumor selectivity, nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor microenvironment (TME) is characterized by hypoxia, acidic pH, and high levels of H2O2, GSH, and proteases. To overcome the shortcomings of canonical phototherapy and achieve optimal theranostic effects with minimal side effects, unique TME characteristics are employed in the development of phototherapeutic nanomedicines. In this review, the effectiveness of three strategies for developing advanced phototherapeutics based on various TME characteristics is examined. The first strategy involves targeted delivery of phototherapeutics to tumors with the assistance of TME‐induced nanoparticle disassembly or surface modification. The second strategy involves near‐infrared absorption increase‐induced phototherapy activation triggered by TME factors. The third strategy involves enhancing therapeutic efficacy by ameliorating TME. The functionalities, working principles, and significance of the three strategies for various applications are highlighted. Finally, possible challenges and future perspectives for further development are discussed.

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Section: Tme‐induced Targeted Delivery Of Phototherapeuticsmentioning

confidence: 99%

“…[ 9 ] In contrast, hypoxia is a common phenomenon in tumors, due to inadequate and poorly organized vasculature. [ 10 ] Moreover, PDT consumes oxygen and further aggravates hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Jia

Feng

et al. 2023

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“…The high intense peak at 568 nm is attributed to the F-defect centers (oxygen vacancies occupied by two electrons) present in MgAl 2 O 4 and peaks at 460 and 670 nm are due to F 2 2 + and F 2 1 + (two associated oxygen vacancies occupied by three electrons), respectively. [48][49][50][51] (2) Figure 9b, c has a broad emission peak at 460 nm and 590 nm, respectively. These emission peaks are attributed to the emission from the F 2 2 + centers and F-centers, respectively, present in the host MgAl 2 O 4 lattice.…”

Section: The Following Are the Conclusion Drawn From The Fs Shown In ...mentioning

confidence: 99%

Luminescence study of Dy³⁺ doped magnesium aluminate phosphors for white light

Kaur

Rani

2023

Zeitschrift anorg allge chemie

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Pure MgAl2O4 and a series of Dysprosium (Dy3+) doping in MgAl2O4 nanoparticles has synthesized using wet chemical sol‐gel method and prepared samples were sintered at 1100 °C. X‐ray diffraction analysis confirms the cubic phase of MgAl2O4 spinel without any impurity in phase even with different doping concentrations of Dy3+ (0.2–1.8 mol %). Under ultraviolet irradiation (283 nm) the fluorescence spectrum of pure MgAl2O4 shows maximum emission in the green‐yellow region. On Dy3+ doping in MgAl2O4, broad emission spectra have been observed due to energy transition that takes place between the host and dopant. To explore the nanophosphor for white light, chromaticity coordinates (CIE), color temperature (CCT), color rendering index (CRI) and color purity were analyzed and at 1.4 mol % doping concentration of Dy3+ in MgAl2O4 got best results i. e. CIE co‐ordinates (0.3326, 0.3334), CCT (5487), CRI (95) and minimum value of color purity (0.20 %). It is observed that emission shifts from yellow‐green to nearly white light emission as the doping is incorporated into the host. It is found that the prepared nanophosphors are energy efficient white light material.

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“…The optical information was encoded azimuthally in the DOEs and retrieved by rotating the DOEs relative to each other. It is to highlight that reconfigurable materials such as phase change materials, semiconductor layers, and MEMS structures integrated with metasurface structures [ 31–36 ] are also good candidates to realize reconfigurable terahertz devices and holograms.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning Enables Multi‐Degree‐of‐Freedom Reconfigurable Terahertz Holograms with Cascaded Diffractive Optical Elements

Jia

Lin

Sensale‐Rodriguez

2023

Advanced Optical Materials

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In this context, terahertz holograms enabled by single-layer diffractive optical elements have been widely explored. [11,18,19,26] However, the reconfigurability of single-layer passive diffractive optical elements is very limited. Cascaded DOE structures have the advantage of enabling more functionality and information capacity compared to single-layer DOEs, as discussed in ref. [27]. Liao et al. [28] studied terahertz reconfigurable holographic imaging by mechanical translation of an absorber relative to two fixed discrete dielectric DOEs. Cascaded computer-generated phase-only diffractive optical elements for multiplane image formation were simulated by Alkan et al. [29] A lens was utilized in such a cascaded configuration for Fourier transform to project patterns on two imaging planes. In the visible range, Wang et al. [30] demonstrated azimuthal multiplexing with a stratified DOE layout optimized by iterative optimization algorithms. The optical information was encoded azimuthally in the DOEs and retrieved by rotating the DOEs relative to each other. It is to highlight that reconfigurable materials such as phase change materials, semiconductor layers, and MEMS structures integrated with metasurface structures [31][32][33][34][35][36] are also good candidates to realize reconfigurable terahertz devices and holograms.Diffractive optical neural networks (DONN) [12] have been successfully applied for the classification of handwritten digit images, [12,37] the design of spatially controlled wavelength demultiplexing systems, [38] and terahertz pulse shaping. [39] Such a machine learning method is an efficient and powerful tool for designing diffractive optics inverse problems in cascaded configurations. The pixel phase (height distributions) in the diffractive layers can be trained by stochastic gradient descent and error-backpropagation to achieve the desired diffraction pattern as the incident beam passes through the diffractive layers.The purpose of this work is to show that through such a DONN machine learning method, it is possible to realize holograms with a tailored reconfigurable operation when altering multiple degrees of freedom, i.e., either the number, spacing, rotational alignment, and/or order of the cascaded diffractive layers. The height distributions of the diffractive layers are trained by the network on the basis of an initial incident terahertz field distribution and predefined (target) diffraction patterns.For our proof-of-concept demonstration, five scenarios are demonstrated, each corresponding to the variation of an individual degree of freedom in the cascaded configuration. A Machine learning can empower the design of cascaded diffractive optical elements (DOEs) at terahertz frequencies enabling the realization of holograms with a tailored multi-degree-of-freedom reconfigurable operation when altering either the number, spacing, rotational alignment, and/or order of the elements. This unprecedented control over the spatial terahertz light distribution can profoundly impact multiple terahe...

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Spatiotemporal Lineshape Tailoring in BIC‐Mediated Reconfigurable Metamaterials (Adv. Funct. Mater. 34/2022)

Cited by 15 publications

References 0 publications

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Luminescence study of Dy³⁺ doped magnesium aluminate phosphors for white light

Machine Learning Enables Multi‐Degree‐of‐Freedom Reconfigurable Terahertz Holograms with Cascaded Diffractive Optical Elements

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Spatiotemporal Lineshape Tailoring in BIC‐Mediated Reconfigurable Metamaterials (Adv. Funct. Mater. 34/2022)

Cited by 15 publications

References 0 publications

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Luminescence study of Dy3+ doped magnesium aluminate phosphors for white light

Machine Learning Enables Multi‐Degree‐of‐Freedom Reconfigurable Terahertz Holograms with Cascaded Diffractive Optical Elements

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Luminescence study of Dy³⁺ doped magnesium aluminate phosphors for white light