Spatiotemporal Distribution of Calcium Oxalate Crystals in a Microchannel
Paszkál Papp,
Samantha Bourg,
Michael Emmanuel
et al.
Abstract:The formation of crystals under physicochemical and flow
dynamic
conditions in constrained dimensions is ubiquitous in nature and of
great interest to different disciplines in science. In this report,
using a physicochemical approach, we investigated the spatiotemporal
precipitation of calcium oxalate (CaOx) crystals, the most common
chemical compound found in kidney stones, at the dynamic interface
generated by the interdiffusion of oxalate and calcium ions in a microchannel.
Spatiotemporal crystal habit dist… Show more
“…20–22 Our team has previously studied CaOx precipitation after co-mixing of supersaturated calcium and oxalate aqueous solutions using a microfluidic platform under physicochemical conditions mimicking those of pathological CaOx KS formation in a nephron collecting duct. 23–25 CaOx stones exhibit two crystalline phases, the more thermodynamically stable monohydrate whewellite (CaC 2 O 4 ·H 2 O, COM) and the dihydrate weddellite (CaC 2 O 4 ·2H 2 O, COD). The identification of CaOx crystals by scanning electron microscopy (SEM) and Raman scattering was made possible thanks to the reversible magnetic sealing system of the microfluidic cell; we were able to show the preferential precipitation of COM crystals in a boat-like shape in agreement with in vivo observations.…”
Effective prevention of recurrent kidney stone’s diseases requires the understanding of their mechanisms of formation. Numerous in vivo observations have demonstrated that a large number of pathological calcium oxalate kidney...
“…20–22 Our team has previously studied CaOx precipitation after co-mixing of supersaturated calcium and oxalate aqueous solutions using a microfluidic platform under physicochemical conditions mimicking those of pathological CaOx KS formation in a nephron collecting duct. 23–25 CaOx stones exhibit two crystalline phases, the more thermodynamically stable monohydrate whewellite (CaC 2 O 4 ·H 2 O, COM) and the dihydrate weddellite (CaC 2 O 4 ·2H 2 O, COD). The identification of CaOx crystals by scanning electron microscopy (SEM) and Raman scattering was made possible thanks to the reversible magnetic sealing system of the microfluidic cell; we were able to show the preferential precipitation of COM crystals in a boat-like shape in agreement with in vivo observations.…”
Effective prevention of recurrent kidney stone’s diseases requires the understanding of their mechanisms of formation. Numerous in vivo observations have demonstrated that a large number of pathological calcium oxalate kidney...
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