Spatiotemporal control of photothermal heating using pH sensitive near-infrared croconaine-based dyes

Alejo, Teresa; Font, Clara; Abad, Miriam; Andreu, Vanesa; Sebastián, Víctor; Mendoza, Gracia; Arruebo, Manuel

doi:10.1016/j.jphotochem.2019.111936

Cited by 7 publications

(1 citation statement)

References 39 publications

(65 reference statements)

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“…Croconaines can absorb in the NIR region at higher wavelengths than squaraines and exhibit enhanced fluorescence properties, making them outstanding for biomedical applications [ 272 ]. As such, they are described in the recent literature as extraordinary molecules with potential use in diagnostic techniques (for example, brain tumors [ 273 ]), as well as in PDT approaches and photothermal [ 274 , 275 ] and, consequently, as theranostic agents [ 272 ].…”

Section: N -Heterocyclic-bearing Dyes As Photodynamic Therap...mentioning

confidence: 99%

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Lima

Reis

2023

Molecules

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Photodynamic therapy, an alternative that has gained weight and popularity compared to current conventional therapies in the treatment of cancer, is a minimally invasive therapeutic strategy that generally results from the simultaneous action of three factors: a molecule with high sensitivity to light, the photosensitizer, molecular oxygen in the triplet state, and light energy. There is much to be said about each of these three elements; however, the efficacy of the photosensitizer is the most determining factor for the success of this therapeutic modality. Porphyrins, chlorins, phthalocyanines, boron-dipyrromethenes, and cyanines are some of the N-heterocycle-bearing dyes’ classes with high biological promise. In this review, a concise approach is taken to these and other families of potential photosensitizers and the molecular modifications that have recently appeared in the literature within the scope of their photodynamic application, as well as how these compounds and their formulations may eventually overcome the deficiencies of the molecules currently clinically used and revolutionize the therapies to eradicate or delay the growth of tumor cells.

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