Spatiotemporal clusters of schistosomiasis mortality and association with social determinants of health in the Northeast region of Brazil (1980–2017)

Paz, Wandklebson Silva da; Gomes, Dharliton Soares; Ramos, Rosália Elen Santos; Cirilo, Tatyane Martins; Santos, Israel Gomes de Amorim; Ribeiro, Caíque Jordan Nunes; Araújo, Karina Conceição Gomes Machado de; Jesus, Amélia Maria Ribeiro de; Santos, Allan Dantas dos; Santos, Márcio Bezerra

doi:10.1016/j.actatropica.2020.105668

Cited by 19 publications

(25 citation statements)

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“…More importantly, many of these cases occur in the elderly, and this considerably increases the risk of association with chronic non-infectious diseases as cardiovascular or digestive diseases, and neoplasms. Furthermore, prior studies conducted by our group showed an increase in the schistosomiasis mortality rate in age groups above 60 years [ 4 , 6 ]. Thereby, it suggests the chronicity of the disease, a higher risk of association with comorbidities, and death [ 3 , 7 ].…”

mentioning

confidence: 73%

“…Usually, men are more exposed to S. mansoni infection, due to occupational activities (ie, fishing or farming), or leisure activities [ 6 , 21 , 22 ]. As a result, schistosomiasis death use to be higher in this group [ 4 , 6 , 23 ]. On the other hand, we observed a decreasing time trend in the mortality rate in men, and stability of deaths in women.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the main effective actions to control schistosomiasis in endemic areas include diagnosis, mass treatment with the anthelminthic drug praziquantel, and Biomphalaria snails control [ 4 , 39 , 40 ]. Meanwhile, considering that schistosomiasis is a neglected tropical disease, we suggest that the goal of elimination schistosomiasis as a public health problem by 2030, as established by the WHO, will only be achieved if, in addition to those measures, there are improvements in the sewerage system and adequate water supply in social vulnerable areas in Brazil [ 1 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the improvements in health service strategies, as diagnosis and mass treatment in endemic areas, have dropped the number of cases and deaths and increased life expectancy for ill patients [ 3 ]. Regardless all these measures, schistosomiasis remains endemic in many states, mainly in the Northeast region [ 4 , 5 ]. PCE estimates point to 1.5 million individuals infected with S. mansoni in Brazil.…”

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confidence: 99%

“…In that regard, temporal and spatial analysis techniques are one of the most efficient methods, since they allow to monitor the impacts of the disease over time and in space [ 9 , 11 ]. Several studies have used spatial and spatiotemporal analysis tools to comprehend the dynamics of schistosomiasis in Brazil [ 4 , 6 , 12 ]. Nevertheless, there are no studies investigating the associated causes of death from the disease at the national level.…”

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confidence: 99%

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Basic and associated causes of schistosomiasis-related mortality in Brazil: A population-based study and a 20-year time series of a disease still neglected

et al. 2021

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Background Schistosomiasis is a persistent public health problem in Brazil. Regardless advances in diagnosis and mass treatment, schistosomiasis has a severe impact on morbimortality in the country and remains a neglected tropical disease. Herein, we assessed the basic and associated causes of schistosomiasis-related deaths and the temporal and spatial patterns of mortality from the disease in Brazil between 1999 and 2018. Methods We conducted an ecological and time series study. The segmented log-linear regression model was applied to assess time trends, considering all deaths recorded in the category B65/ICD-10. Additionally, we elaborated maps of mortality rates from schistosomiasis in Brazil. Results A total of 4168 schistosomiasis-related deaths were recorded in Brazil in this period, as an associated cause. Time trend analysis revealed an increase in the average age of deaths from schistosomiasis (annual percentage change (APC) = 0.84), and stable trend in Brazil (APC = 0.31). Concerning schistosomiasis-related deaths, we observed disorders related to the digestive system, liver diseases, septicemias, and chronic diseases. Surprisingly, there were deaths caused by non-endemic Schistosoma species in Brazil. Also, municipalities from non-endemic areas in Brazil presented schistosomiasis-related deaths. Conclusion Altogether, our analyses demonstrated that schistosomiasis remains a significant cause of death in Brazil, and it is increasing in some areas, especially in the Northeast region. Additionally, women and the elderly showed a stable time trend of deaths. Thereby, it urgently requires improvements in the control programs strategies, in the sense of an effective reduction in cases and deaths from the disease in Brazil.

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confidence: 73%