Spatiotemporal changes in regularity of gamma oscillations contribute to focal ictogenesis

Sato, Yosuke; Wong, Simeon M.; Iimura, Yasushi; Ochi, Ayako; Doesburg, Sam M.; Otsubo, Hiroshi

doi:10.1038/s41598-017-09931-6

Cited by 26 publications

(29 citation statements)

References 54 publications

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“…And while chaotic dynamics might seem counterproductive for the brain, it has been theorized that these patterns are critical for information storage (Aihara et al, 1990;Brunel & Hakim, 2008;Jia et al, 2012;Korn & Faure, 2003). And perhaps fluctuations into the occasional window of stability within this chaos play a role in pathologies such as epilepsy (Sato et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

The Refractory Period Matters: Unifying Mechanisms of Macroscopic Brain Waves

2021

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The relationship between complex brain oscillations and the dynamics of individual neurons is poorly understood. Here we utilize maximum caliber, a dynamical inference principle, to build a minimal yet general model of the collective (mean field) dynamics of large populations of neurons. In agreement with previous experimental observations, we describe a simple, testable mechanism, involving only a single type of neuron, by which many of these complex oscillatory patterns may emerge. Our model predicts that the refractory period of neurons, which has often been neglected, is essential for these behaviors.

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Section: Discussionmentioning

confidence: 99%

The Refractory Period Matters: Unifying Mechanisms of Macroscopic Brain Waves

2021

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“…This suggests that an alteration of the E‐I networks will affect theta‐gamma coupling which will be associated with episodic memory deficits. In addition, changes in spatiotemporal regularities of gamma cycles reflecting modifications in interneuronal synchronization dynamics are associated with focal ictogenesis (Sato et al, ). Local generation of gamma oscillations ahead of interictal epileptiform discharges (IA) reflects a role of these oscillations in pathological associated networks generating IA and may be used as useful association (gamma‐IA) in clinics to map seizure‐prone brain regions (Ren et al, ).…”

Section: How Is Tl‐dependent Cognition Altered In Temporal Lobe Epilementioning

confidence: 99%

Update on temporal lobe‐dependent information processing, in health and disease

Chauvière

2019

Eur J of Neuroscience

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The past decade has been characterized by a lot of remodeling in the field of learning and memory. Both of them, often associated with neuronal oscillations, an emergent property of brain networks, are governed by temporal lobe (TL) functional connectivity. An impairment of oscillatory mechanisms indeed often leads to TL‐dependent cognitive deficits. While the classical view assigned the TL a major role in spatial information processing, new theories rather confer to the TL a more general function in cognitive processes beyond space representation. The present review covers, both in humans and in animal models, (a) the updated role of the TL in cognitive processes, addressing current debates in the field and proposing a scenario on how TL structures cooperate in order to bind an integrated representation of afferent information, (b) the oscillatory mechanisms underlying these TL‐dependent cognitive functions (theta, gamma, sharp wave ripples) and (c) how TL‐dependent cognition is altered during temporal lobe epilepsy, proposing a scenario on how reorganized TL networks in TLE leads to rhythmopathies and cognitive deficits. Temporal lobe epilepsy (TLE) is a well‐studied neurological disease. Patients do not only suffer from epileptic seizures but also from cognitive and behavioral deficits between their seizures called comorbidities. TLE animal models are therefore used to understand how and when these comorbidities arise and what their underlying mechanisms are.

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“…[12][13][14] We recently showed that high gamma oscillation (30-70 Hz) regularity (GOR) calculated with interictal ECoG data analysis could sensitively detect the epileptogenic zone in focal cortical dysplasia. 15,16 We hypothesized and tested whether this method could also be applied to epileptogenic zone localization in epilepsy surgery for cavernomas.…”

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confidence: 99%

Epileptogenic zone localization using intraoperative gamma oscillation regularity analysis in epilepsy surgery for cavernomas: patient series

Sato

Tsuji

Kawauchi

et al. 2021

Journal of Neurosurgery: Case Lessons

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BACKGROUNDIn epilepsy surgery for cavernoma with intractable focal epilepsy, removal of the cavernoma with its surrounding hemosiderin deposition and other extended epileptogenic zone has been shown to improve postsurgical seizures. However, there has been no significant association between such an epileptogenic zone and intraoperative electrocorticography (ECoG) findings. The authors recently demonstrated that high regular gamma oscillation (30–70 Hz) regularity (GOR) significantly correlates with epileptogenicity.OBSERVATIONSThe authors evaluated the utility of intraoperative GOR analysis in epilepsy surgery for cavernomas. The authors also analyzed intraoperative ECoG data from 6 patients with cavernomas. The GOR was calculated using a sample entropy algorithm. In 4 patients, the GOR was significantly high in the area with the pathological hemosiderin deposition. In 2 patients with temporal cavernoma, the GOR was significantly high in both the hippocampus and the area with the pathological hemosiderin deposition. ECoG showed no obvious epileptic waveforms in 3 patients, whereas extensive spikes were observed in 3 patients. All patients underwent cavernoma removal plus resection of the area with significantly high GOR. The 2 patients with temporal cavernomas underwent additional hippocampal transection. All patients were seizure free after surgery.LESSONSThe high GOR may be a novel intraoperative marker of the epileptogenic zone in epilepsy surgery for cavernomas.

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Spatiotemporal changes in regularity of gamma oscillations contribute to focal ictogenesis

Cited by 26 publications

References 54 publications

The Refractory Period Matters: Unifying Mechanisms of Macroscopic Brain Waves

The Refractory Period Matters: Unifying Mechanisms of Macroscopic Brain Waves

Update on temporal lobe‐dependent information processing, in health and disease

Epileptogenic zone localization using intraoperative gamma oscillation regularity analysis in epilepsy surgery for cavernomas: patient series

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