Spatio-Temporal Working Memory and Frontal Lesions in Man

Ct, Ferreira; Vérin, Marc; Pillon, B.; Lévy, Richard; Dubois, Bruno; Agid, Yves

doi:10.1016/s0010-9452(08)70738-x

Cited by 42 publications

(20 citation statements)

References 48 publications

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“…A specific frontal involvement in working memory performance has furthermore been suggested by both functional neuroimaging (Narayanan et al, 2005;Wager & Smith, 2003) and lesion studies (Bor, Duncan, Lee, Parr, & Owen, 2006;Ferreira et al, 1998). However, previous studies examining the association between WMH and working memory performance report varying results.…”

Section: Introductionmentioning

confidence: 90%

White Matter Hyperintensities and Working Memory: An Explorative Study

Oosterman

Harten

Weinstein

et al. 2008

Aging, Neuropsychology, and Cognition

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White matter hyperintensities (WMH) are commonly observed in elderly people and may have the most profound effect on executive functions, including working memory. Surprisingly, the Digit Span backward, a frequently employed working memory task, reveals no association with WMH. In the present study, it was investigated whether more detailed analyses of WMH variables and study sample selection are important when establishing a possible relationship between the Digit Span backward and WMH. To accomplish this, the Digit Span backward and additional working memory tests, WMH subscores, and cardiovascular risk factors were examined. The results revealed that performance on the Digit Span backward test is unrelated to WMH, whereas a relationship between other working memory tests and WMH was confirmed. Furthermore, a division between several white matter regions seems important; hyperintensities in the frontal deep white matter regions were the strongest predictor of working memory performance.

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Section: Introductionmentioning

confidence: 90%

White Matter Hyperintensities and Working Memory: An Explorative Study

Oosterman

Harten

Weinstein

et al. 2008

Aging, Neuropsychology, and Cognition

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“…Although recent data suggest temporal lobe involvement in the allocentric spatial tasks described above, temporal lobe lesions have little effect on spatial span (Corsi, 1972;Ferreira et al, 1998;Gagnon, Foster, Turcotte, & Jongenelis, 2004;Rausch & Ary, 1990). A possible interpretation is that the reference frame used in spatial span differs from that used in spatial navigation tasks, and indeed one proposal is that the spatial span task relies on egocentric rather than allocentric encoding (Aguirre & D'Esposito, 1999).…”

Section: Neuropsychological Studies Of Memory For Positionmentioning

confidence: 98%

“…The intrinsic, templatecentered representation that appears to support spatial span would seem to be quite different from the viewpointindependent spatial descriptions that support navigation. From a neuropsychological perspective, spatial span is sensitive to parietal rather than temporal lesions (Corsi, 1972;Ferreira et al, 1998;Gagnon et al, 2004;Rausch & Ary, 1990). Although it is tempting to attribute the neuropsychological dissociation to the demands posed by different spatial reference frames, other interpretations are possible.…”

Section: Implications For Spatial Spanmentioning

confidence: 99%

Spatial span under translation: A study of reference frames

Avons

2007

Memory & Cognition

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The nature of the reference frame used to remember location sequences in a computer-presented version of spatial span was investigated by moving the template (a rectangular frame enclosing nine target squares) across the screen during presentation and/or during recall. Movement of the display during presentation substantially impaired memory in comparison with a stationary display (Experiment 1). However, there was no effect of template movement during recall (Experiment 2). In Experiments 3 and 4, the template was moved through the same screen locations during presentation and recall. When the extrinsic, or screen location, of each position was repeated identically on each trial but the sequence on the template varied, learning was not facilitated (Experiment 3). When the template sequences were repeated across trials but extrinsic location varied, the sequences were rapidly learned (Experiment 4). In this version of spatial span, location sequences appear to be encoded in an intrinsic frame of reference that is based on the template. Movement of the template during encoding impairs this process, possibly because concurrent attention shifts prevent the encoding of locations. The results are discussed with respect to recent studies of positional encoding in which multiple reference frames were available. Memory & Cognition 2007, 35(3), 402-417 S. E. Avons, savons@essex.ac.uk

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“…In the delayedresponse task, no control patients made errors, only 2 of the 10 posterior patients made errors, yet 7 of the 10 frontal patients made errors. Ferreira et al (1998) tested mixedetiology patients in a computerized delayed-response task with 500-msec versus 10-sec delays. Eight patients with unilateral frontal lesions (most including dPFC) and 10 patients with unilateral inferior temporal lesions were each compared with patients in an age-matched, healthy control group.…”

Section: Human Researchmentioning

confidence: 99%