Spatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe

Müller, Thomas; Schröder, Ronald; Wysocki, Patrick; Mettenleiter, Thomas C.; Freuling, Conrad Martin

doi:10.1371/journal.pntd.0003953

Cited by 90 publications

(85 citation statements)

References 34 publications

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“…Rabies control programmes for foxes and raccoon dogs should be complemented by appropriate management measures in stray dogs and cat population (population registry, control and vaccination). It was shown that the successful elimination of fox rabies is a result of interaction of different key components during oral rabies vaccination campaigns such as vaccine strain, vaccine bait and strategy of distribution on a temporal and spatial scale (Müller et al., ). Rabies in pets imported from endemic countries is regularly reported in Europe, highlighting the need for continued vigilance concerning pet movements and campaigns to raise awareness among pet owners (Ribadeau‐Dumas et al., ).…”

Section: Discussionmentioning

confidence: 99%

The European Union summary report on trends and sources of zoonoses, zoonotic agents and food‐borne outbreaks in 2015

2016

EFS2

253

100

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This report of EFSA and the European Centre for Disease Prevention and Control presents the results of the zoonoses monitoring activities carried out in 2015 in 32 European countries (28 Member States (MS) and four non-MS). Campylobacteriosis was the most commonly reported zoonosis and the increasing European Union (EU) trend for confirmed human cases since 2008 continued. In food, the occurrence of Campylobacter remained high in broiler meat. The decreasing EU trend for confirmed human salmonellosis cases since 2008 continued, but the proportion of human Salmonella Enteritidis cases increased. Most MS met their Salmonella reduction targets for poultry. More S. Enteritidis isolates were reported and S. Infantis was confirmed as the most frequent serovar isolated from domestic fowl. In foodstuffs, the EU level Salmonella non-compliance for minced meat and meat preparations from poultry was low. Despite the significant increasing trend since 2008, the number of human listeriosis cases stabilised in 2015. In ready-to-eat foods, Listeria monocytogenes seldom exceeded the EU food safety limit. The decreasing EU trend for confirmed yersiniosis cases since 2008 continued. Positive findings for Yersinia were mainly reported in pig meat and products thereof. The number of confirmed shiga toxin-producing Escherichia coli (STEC) infections in humans was similar to 2014. In food, STEC was most frequently reported in meat from ruminants. A total of 4,362 food-borne outbreaks, including waterborne outbreaks, were reported. Bacteria were the most commonly detected causative agents, followed by bacterial toxins, viruses, other causative agents and parasites. The causative agent remained unknown in 33.5% of all outbreaks. As in previous years, Salmonella in eggs continued to represent the highest risk agent/food combination. The report further summarises trends and sources for tuberculosis due to Mycobacterium bovis, Brucella, Trichinella, Echinococcus, Toxoplasma, rabies, Coxiella burnetii (Q fever), West Nile virus and tularaemia.

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Section: Discussionmentioning

confidence: 99%

The European Union summary report on trends and sources of zoonoses, zoonotic agents and food‐borne outbreaks in 2015

2016

EFS2

253

100

View full text Add to dashboard Cite

show abstract

“…Rabies control programmes for foxes and raccoon dogs should be complemented by appropriate management measures in stray dogs and cats (population registry, control and vaccination). It was shown that the successful elimination of fox rabies is a result of interaction of different key components during oral rabies vaccination campaigns such as vaccine strain, vaccine bait and strategy of distribution on a temporal and spatial scale (Müller et al, 2015). Rabies in pets imported from endemic countries is regularly reported in Europe (the most recent case in 2015, a dog imported from Algeria to France), highlighting the need for continued vigilance concerning pet movements and campaigns to raise awareness amongst pet owners.…”

Section: Discussionmentioning

confidence: 99%

The European Union summary report on trends and sources of zoonoses, zoonotic agents and food‐borne outbreaks in 2014

2015

EFS2

231

118

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VTEC was reported from food and animals. A total of 5,251 food-borne outbreaks, including waterborne outbreaks, were reported. Most food-borne outbreaks were caused by viruses, followed by Salmonella, bacterial toxins and Campylobacter and with unknown causative agent in 29.1% of all outbreaks. Important food vehicles in strong-evidence food-borne outbreaks were 'eggs and egg products', followed by 'mixed food' and 'crustaceans, shellfish, molluscs and products thereof'. The report further summarises trends and sources along the food chain of tuberculosis due to Mycobacterium bovis, Brucella, Trichinella, Echinococcus, Toxoplasma, rabies, Coxiella burnetii

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“…In Canada for example, the ERA-BHK21vaccine virus strain, a derivative of the cell culture adapted vaccine virus strain Street Alabama Dufferin (SAD) [5,6], was the only live attenuated vaccine deployed in fox ORV campaigns [7]. In Europe, with the exception of a recombinant vaccinia virus expressing the rabies virus glycoprotein, all constructs have been based on live attenuated rabies virus strains [4], derived from the SAD Bern original (SAD Bern orig ) vaccine virus strain, a successor of the ERA strain [2,8]. While all these vaccines have been highly efficient in fox rabies control, the first generation of SAD-derived vaccines demonstrated residual pathogenicity in non-target species particularly in rodents [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns

Calvelage

Smreczak

Orłowska

et al. 2020

Viruses

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Rabies in wildlife has been successfully controlled in parts of Europe and North America using oral rabies vaccination, i.e., the distribution of baits containing live-attenuated virus strains. Occasionally, these vaccines caused vaccine virus-induced rabies cases. To elucidate the mechanisms of genetic selection and the effect of viral populations on these rabies cases, a next generation sequencing approach as well as comprehensive data analyses of the genetic diversity of Street Alabama Dufferin (SAD) and ERA vaccine virus strains and vaccine-induced rabies cases from Canada and several European countries were conducted. As a result, twelve newly generated sets of sequencing data from Canada and Poland were added to a pool of previously investigated samples. While the population-based analysis showed a segregation of viruses of ERA vaccine-induced rabies cases from those of SAD Bern original (SAD Bern orig )-derived rabies cases, the in-depth variant analysis revealed three distinct combinations of selected variants for the ERA vaccine-induced cases, suggesting the presence of multiple replication-competent haplotypes in the investigated ERA-BHK21 vaccine. Our findings demonstrate the potential of a deep sequencing approach in combination with comprehensive analyses on the consensus, population, and variant level.

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Spatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe

Cited by 90 publications

References 34 publications

The European Union summary report on trends and sources of zoonoses, zoonotic agents and food‐borne outbreaks in 2015

The European Union summary report on trends and sources of zoonoses, zoonotic agents and food‐borne outbreaks in 2015

The European Union summary report on trends and sources of zoonoses, zoonotic agents and food‐borne outbreaks in 2014

Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns

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