Spatio-temporal source cluster analysis reveals fronto-temporal auditory change processing differences within a shared autistic and schizotypal trait phenotype

Ford, Talitha C.; Woods, Will; Crewther, DP

doi:10.1016/j.nicl.2017.04.022

Cited by 11 publications

(7 citation statements)

References 48 publications

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“…Furthermore, psychosocial dysfunction – the central feature of the Social Disorganisation phenotype – has been associated with an increased excitation/inhibition ratio ( Yizhar et al, 2011 ). Finally, auditory processing deficits are reported across the autism and schizophrenia spectra ( Kompus et al, 2015 , Gandal et al, 2012 , Rossignol, 2011 , Ford et al, 2017a , Ford et al, 2017b ), and these deficits have been related to glutamate and GABA concentrations ( Kompus et al, 2015 ), and social and interpersonal impairment ( Fulham et al, 2014 , Rasser et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Increased glutamate/GABA+ ratio in a shared autistic and schizotypal trait phenotype termed Social Disorganisation

Ford

Nibbs

Crewther

2017

NeuroImage: Clinical

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Autism and schizophrenia are multi-dimensional spectrum disorders that have substantial phenotypic overlap. This overlap is readily identified in the non-clinical population, and has been conceptualised as Social Disorganisation (SD). This study investigates the balance of excitatory glutamate and inhibitory γ-aminobutyric acid (GABA) concentrations in a non-clinical sample with high and low trait SD, as glutamate and GABA abnormalities are reported across the autism and schizophrenia spectrum disorders.Participants were 18 low (10 females) and 19 high (9 females) SD scorers aged 18 to 40 years who underwent 1H-MRS for glutamate and GABA+macromolecule (GABA+) concentrations in right and left hemisphere superior temporal (ST) voxels.Reduced GABA+ concentration (p = 0.03) and increased glutamate/GABA+ ratio (p = 0.003) in the right ST voxel for the high SD group was found, and there was increased GABA+ concentration in the left compared to right ST voxel (p = 0.047). Bilateral glutamate concentration was increased for the high SD group (p = 0.006); there was no hemisphere by group interaction (p = 0.772).Results suggest that a higher expression of the SD phenotype may be associated with increased glutamate/GABA+ ratio in the right ST region, which may affect speech prosody processing, and lead behavioural characteristics that are shared within the autistic and schizotypal spectra.

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Section: Introductionmentioning

confidence: 99%

Increased glutamate/GABA+ ratio in a shared autistic and schizotypal trait phenotype termed Social Disorganisation

Ford

Nibbs

Crewther

2017

NeuroImage: Clinical

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“…This finding supports a role of the anterior insular cortex in pre-attentive processing of emotional salience [67]. Using an MMN/field paradigm, Ford et al reported significantly reduced right hemisphere fronto-temporal and insular cortex activation in a “high social disorganization” group sharing autistic and schizotypal phenotypes, and indicated that right fronto-temporal and insular cortex-related auditory change processing may be associated with psychosocial functioning [68]. The insular cortex not only relays information to and from somatosensory, auditory, and visual areas and the amygdala, which has been suggested to be involved in emotion and fear processing [64], but is among the secondary auditory cortices, with connections to the STG and dorsal superior temporal sulcus [69].…”

Section: Discussionmentioning

confidence: 52%

“…Changes in the structure of the insular cortex have been identified in patients with schizophrenia and autism [71]. Connections between these regions may be disrupted in schizophrenia, disrupting feedback pathways from the IFG to the STG, suggesting a deficit in the connection between the auditory processing regions and the IFG [68]. These previous literatures suggesting a key role of the fronto-temporal-limbic cortical networks in MMN generation may support our findings that BOLD activation of Heschl’s gyri correlated with that of the limbic system, including the insula.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous fMRI-EEG-DTI recording of MMN in patients with schizophrenia

et al. 2019

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Functional magnetic resonance imaging (fMRI), electroencephalogram (EEG), and diffusion tensor imaging (DTI) recording have complementary spatiotemporal resolution limitations but can be powerful methods when used together to enable both functional and anatomical modeling, with each neuroimaging procedure used to maximum advantage. We recorded EEGs during event-related fMRI followed by DTI in 15 healthy volunteers and 12 patients with schizophrenia using an omission mismatch negativity (MMN) paradigm. Blood oxygenation level-dependent (BOLD) signal changes were calculated in a region of interest (ROI) analysis, and fractional anisotropy (FA) in the white matter fibers related to each area was compared between groups using tract-specific analysis. Patients with schizophrenia had reduced BOLD activity in the left middle temporal gyrus, and BOLD activity in the right insula and right parahippocampal gyrus significantly correlated with positive symptoms on the Positive and Negative Syndrome Scale (PANSS) and hostility subscores. BOLD activation of Heschl’s gyri also correlated with the limbic system, including the insula. FA values in the left anterior cingulate cortex (ACC) significantly correlated with changes in the BOLD signal in the right superior temporal gyrus (STG), and FA values in the right ACC significantly correlated with PANSS scores. This is the first study to examine MMN using simultaneous fMRI, EEG, and DTI recording in patients with schizophrenia to investigate the potential implications of abnormalities in the ACC and limbic system, including the insula and parahippocampal gyrus, as well as the STG. Structural changes in the ACC during schizophrenia may represent part of the neural basis for the observed MMN deficits. The deficits seen in the feedback/feedforward connections between the prefrontal cortex and STG modulated by the ACC and insula may specifically contribute to impaired MMN generation and clinical manifestations.

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“…It has been shown that prediction errors reduce with increasing delusional-like experiences in healthy populations (Corlett, 2012). Furthermore, the trait phenotype social disorganization, which is shared by autism and schizotypy, has been linked to reduced fronto-temporal response to deviant tones in a magnetoencephalography study (Ford et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Auditory prediction errors and auditory white matter microstructure as predictors of psychotic experiences in healthy individuals

Randeniya

Oestreich

Garrido

2019

Preprint

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Our sensory systems actively predict sensory information based on previously learnt patterns. An inability to accurately predict forthcoming information results in prediction errors. Individuals with schizophrenia consistently show reduced auditory prediction errors as well as reduced microstructure in auditory white matter pathways. However, it is not clear if also healthy individuals with psychotic experiences demonstrate such deficits. Participants underwent electroencephalography (EEG) recordings while listening to a simple two-tone duration deviant oddball paradigm (N=103) and a stochastic oddball paradigm (N=89). A subset of participants (N=89) also underwent diffusion-weighted magnetic resonance imaging (MRI), from which fractional anisotropy (FA), a measure of overall white matter microstructure, was obtained for auditory pathways namely the auditory interhemispheric pathway, as well as the left and right arcuate fasciculi. We investigated both structural and functional predictors of positive psychotic experiences in healthy participants as measured by the Community Assessment for Psychic Experiences positive dimension (CAPE+) scores. Prediction errors evokedby the classical oddball paradigm failed to reveal significant effects, whereas the stochastic oddball paradigm revealed significant clusters at typical mismatch negativity periods predictive of CAPE+ scores. Furthermore, we show that white matter microstructure from auditory pathways in addition to mismatches significantly predict CAPE+ scores. We suggest that structural and functional prediction error measures together may have potential in predicting psychotic experiences in the healthy population.3

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Spatio-temporal source cluster analysis reveals fronto-temporal auditory change processing differences within a shared autistic and schizotypal trait phenotype

Cited by 11 publications

References 48 publications

Increased glutamate/GABA+ ratio in a shared autistic and schizotypal trait phenotype termed Social Disorganisation

Increased glutamate/GABA+ ratio in a shared autistic and schizotypal trait phenotype termed Social Disorganisation

Simultaneous fMRI-EEG-DTI recording of MMN in patients with schizophrenia

Auditory prediction errors and auditory white matter microstructure as predictors of psychotic experiences in healthy individuals

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