Abstract:Recent innovations in drug therapies in rheumatoid arthritis (RA) have made it highly desirable to obtain sensitive biomarkers of disease progression that can be used to quantify the performance of candidate disease modifying drugs. We present a spatio-temporal analysis technique to automatically quantify small changes in a bone in in-vivo serial MR images from an experimental model of RA. The technique integrates the time-domain information across all the time points by building a 5-dimensional feature space … Show more
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