2019
DOI: 10.1371/journal.pgen.1007959
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Spatio-temporal regulation of nuclear division by Aurora B kinase Ipl1 in Cryptococcus neoformans

Abstract: The nuclear division takes place in the daughter cell in the basidiomycetous budding yeast Cryptococcus neoformans . Unclustered kinetochores gradually cluster and the nucleus moves to the daughter bud as cells enter mitosis. Here, we show that the evolutionarily conserved Aurora B kinase Ipl1 localizes to the nucleus upon the breakdown of the nuclear envelope during mitosis in C . neoformans . Ipl1 is shown to be required for timely breakdow… Show more

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Cited by 21 publications
(93 citation statements)
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“…6f). The sharp reduction of AuroraB Ipl1 localization at anaphase kinetochores 48 and essentiality of amino-terminus of CENP-C Mif2 (Supplementary Fig. 6e and data not shown) are observed in C. neoformans.…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…6f). The sharp reduction of AuroraB Ipl1 localization at anaphase kinetochores 48 and essentiality of amino-terminus of CENP-C Mif2 (Supplementary Fig. 6e and data not shown) are observed in C. neoformans.…”
Section: Discussionmentioning
confidence: 87%
“…We subsequently examined how bgi1Δ affected cell cycle progression. For this, microscopic markers to determine cell cycle stages previously determined 44, 48 were used and summarized in Supplementary Fig. 3c.…”
Section: Resultsmentioning
confidence: 99%
“…The kinetochores were shown to be randomly localized along the spindle axis having aberrant kMT lengths (Tytell and Sorger, ; Gardner et al , ; Marco et al , ). Recently, dynamic localization of Ipl1 has been shown to regulate the integrity of MTs required for timely nuclear migration and kinetochore clustering in Cryptococcus neoformans (Varshney et al , ).…”
Section: Introductionmentioning
confidence: 99%
“…Like S. cerevisiae, cells divide by budding in C. neoformans as well (Fig 1, S1 Video). The major sequence of mitotic events from the formation of bud until chromosome segregation in C. neoformans can be categorized in the following temporal order: (a) Bud inception at the end of G1/onset of S phase [16], (b) clustering of KTs as a single punctum at the periphery of nucleus after bud initiation [16] (Fig 1, S1 Video), (c) nuclear migration into the daughter bud followed by spindle formation; (d) localization of the spindle near the bud-neck junction/septin ring (Fig 1) and eventually (e) equal nuclear division mother and daughter bud (Fig 1, S1 Video).…”
Section: Introductionmentioning
confidence: 99%
“…(b) In S. cerevisiae, the KTs are grouped into a single cluster and KT attachments to the SPBs by MTs are maintained through most of the cell cycle [23,[28][29][30]. Contrary to that, in C. neoformans, KTs are unclustered during interphase [15,16,25]. As the cell advances through the cell cycle, the KTs gradually cluster into a single punctum, plausibly via various MT mediated interactions.…”
Section: Introductionmentioning
confidence: 99%