2007
DOI: 10.1186/1477-7827-5-27
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Spatio-temporal expression of MMP-2, MMP-9 and tissue kallikrein in uteroplacental units of the pregnant guinea-pig (Cavia porcellus)

Abstract: Background: In humans trophoblast invasion and vascular remodeling are critical to determine the fate of pregnancy. Since guinea-pigs share with women an extensive migration of the trophoblasts through the decidua and uterine arteries, and a haemomonochorial placenta, this species was used to evaluate the spatio-temporal expression of three enzymes that have been associated to trophoblast invasion, MMP-2, MMP-9 and tissue kallikrein (K1).

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Cited by 21 publications
(23 citation statements)
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“…Stimulation of the B2R induces MMP overexpression and cell migration in a rat astroglial cell line [39], while the B1R induces release of MMP-2 and MMP-9 in breast cancer cells [37]. Co-localization of MMP-9 and the B2R was observed in our previous studies in guinea-pig extravillous trophoblast [46]. The co-localization of MMP-9 and MMP-2 with the B2R was confirmed in HTR-8/SVneo cells by immunohistochemistry and enzymatic activity in this study.…”
Section: Discussionmentioning
confidence: 96%
“…Stimulation of the B2R induces MMP overexpression and cell migration in a rat astroglial cell line [39], while the B1R induces release of MMP-2 and MMP-9 in breast cancer cells [37]. Co-localization of MMP-9 and the B2R was observed in our previous studies in guinea-pig extravillous trophoblast [46]. The co-localization of MMP-9 and MMP-2 with the B2R was confirmed in HTR-8/SVneo cells by immunohistochemistry and enzymatic activity in this study.…”
Section: Discussionmentioning
confidence: 96%
“…Gelatinase activity was detected by zymography using methods described previously with some modifications [16]. PVAT homogenates (50 μg/lane) were resolved under non-reducing conditions in an 8% polyacrylamide gel containing 0.5 mg/ml gelatin (Merck, Darmstadt, Germany).…”
Section: Methodsmentioning
confidence: 99%
“…Under normal physiological conditions, MMPs are known to regulate cellular migration, invasion, and angiogenesis during embryonic implantation, whereas under pathological conditions, increased expression and activity of MMPs result in tumor growth, migration, and metastasis, leading to the development of cancer (Corthorn et al 2007). The controlled expression and a proper balance between MMPs and their inhibitors (TIMPs), which determine the net MMP activity (Seval et al 2004) and hence regulate the invasive potential of placental trophoblasts, are pivotal for maintaining normal placentation (Staun-Ram & Shalev 2005).…”
Section: Introductionmentioning
confidence: 99%