Spatio-temporal dynamics of three diseases caused by Aedes-borne arboviruses in Mexico

Dong, Bin; Khan, Latifur; Smith, Madison; Treviño, Jesús; Zhao, Bingxin; Hamer, Gabriel L.; López-Lemus, Uriel A.; Angulo‐Molina, Aracely; Lubinda, Jailos; Nguyen, Uyen‐Sa D. T.; Haque, Ubydul

doi:10.1038/s43856-022-00192-7

Cited by 4 publications

(1 citation statement)

References 53 publications

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“…Arboviruses ( ar thropod-bo rne viruses ) such as Dengue, Zika and Chikungunya (DENV, ZIKV and CHIKV, respectively) impose serious morbidity and mortality burdens worldwide, which have been on the rise over the last two decades [1][2][3][4][5][6][7][8] . Arboviral vectors, mainly Aedes aegypti and to a lesser extent Aedes albopictus , have spread and are now present in Africa, Europe, Asia, Oceania and the Americas [3,5,9] .…”

Section: Introductionmentioning

confidence: 99%

A look into the future: Using a transcriptomic meta-analysis ofDiptera-Wolbachiasystems to project the sustainability of arboviral control strategies

Mejías,

Jiménez,

Conca

et al. 2023

Preprint

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BackgroundAn effective strategy for arboviral control consists in transfectingAedes aegyptimosquitoes with the intracellular bacteriaWolbachia pipientis, which reduces host viral susceptibility and spreads itself into wild populations via reproductive manipulations. However, the prospect of losing the efficacy of this strategy underscores the need for deepening the mechanistic knowledge ofDiptera-Wolbachiasystems and identifying relevantWolbachiaeffects that could decline upon adaptation ofA. aegyptitransfections. A systematic comparison of publicly availableDiptera-Wolbachiatranscriptomic datasets could yield progress in this matter.Methodology/Principal findingsWe derived differentially expressed gene (DEG) sets from previously publishedDiptera-Wolbachiatranscriptomic datasets, subjected them to enrichment analysis of Gene Ontology terms, and intersected the results to identify patterns of host gene/function regulation byWolbachia. A putative farnesoic acid methyl transferase (AAEL004667) and a flavin-containing monooxygenase (AAEL000834) were consistently upregulated in transfectedA. aegyptiand linked to cytoplasmic incompatibility and viral susceptibility, being proposed as novel targets of study. Genes implicated in viral blocking—GNBPA1,PGRPS1,DEFC,Tf1, serine-type endopeptidases and endopeptidase inhibitors— were consistently upregulated in transfectedA. aegyptibut not in native infections, indicating that they could lose responsiveness toWolbachiaover time and should be considered to keep the efficacy of arboviral control. The commonality of chitinase regulation byWolbachiawas identified and proposed as an explanation for the loss of desiccation resistance in transfectedA. aegypti’s eggs, which is a main obstacle for the introgression ofWolbachiain mosquito populations.Conclusions/SignificanceThe present work points out relevant gene targets to consider for arboviral control sustainability and provides new hypotheses for deepening the understanding ofDiptera-Wolbachiasystems.Author SummaryArboviral diseases (e.g. dengue), which are mainly transmitted by the mosquitoAedes aegypti, impose a global public health crisis. An effective strategy for controlling the spread of these diseases is to artificially infectA. aegyptipopulations with the bacteriaWolbachia pipientis, which reduces its capacity to transmit arboviruses. However, future adaptive changes in the novelA. aegypti-Wolbachiaassociation could diminish the efficacy of this approach. To prevent this, it is crucial to have a solid biological understanding ofWolbachiainfections and predictions about specific changes that artificial infections could undergo. By analyzing publicly available biological data fromWolbachia-infected mosquitoes and flies we were able to propose new hypotheses regarding general aspects ofWolbachiainfection and to identify antiviral effects ofWolbachiainA. aegyptithat could decline over time, thus providing relevant information for keeping sustainability of a key arboviral control strategy.

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Section: Introductionmentioning

confidence: 99%

A look into the future: Using a transcriptomic meta-analysis ofDiptera-Wolbachiasystems to project the sustainability of arboviral control strategies

Mejías,

Jiménez,

Conca

et al. 2023

Preprint

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The ecological determinants of severe dengue: A Bayesian inferential model

Annan

Bukhari

Treviño

et al. 2023

Ecological Informatics

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Zika, chikungunya and co-occurrence in Brazil: space-time clusters and associated environmental–socioeconomic factors

Gardini Sanches Palasio,

Marques Moralejo Bermudi,

Luiz de Lima Macedo

et al. 2023

Sci Rep

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Chikungunya and Zika have been neglected as emerging diseases. This study aimed to analyze the space-time patterns of their occurrence and co-occurrence and their associated environmental and socioeconomic factors. Univariate (individually) and multivariate (co-occurrence) scans were analyzed for 608,388 and 162,992 cases of chikungunya and Zika, respectively. These occurred more frequently in the summer and autumn. The clusters with the highest risk were initially located in the northeast, dispersed to the central-west and coastal areas of São Paulo and Rio de Janeiro (2018–2021), and then increased in the northeast (2019–2021). Chikungunya and Zika demonstrated decreasing trends of 13% and 40%, respectively, whereas clusters showed an increasing trend of 85% and 57%, respectively. Clusters with a high co-occurrence risk have been identified in some regions of Brazil. High temperatures are associated with areas at a greater risk of these diseases. Chikungunya was associated with low precipitation levels, more urbanized environments, and places with greater social inequalities, whereas Zika was associated with high precipitation levels and low sewage network coverage. In conclusion, to optimize the surveillance and control of chikungunya and Zika, this study’s results revealed high-risk areas with increasing trends and priority months and the role of socioeconomic and environmental factors.

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Spatio-temporal dynamics of three diseases caused by Aedes-borne arboviruses in Mexico

Cited by 4 publications

References 53 publications

A look into the future: Using a transcriptomic meta-analysis ofDiptera-Wolbachiasystems to project the sustainability of arboviral control strategies

A look into the future: Using a transcriptomic meta-analysis ofDiptera-Wolbachiasystems to project the sustainability of arboviral control strategies

The ecological determinants of severe dengue: A Bayesian inferential model

Zika, chikungunya and co-occurrence in Brazil: space-time clusters and associated environmental–socioeconomic factors

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