Spatio-temporal control strategy of drug delivery systems based nano structures

Rahoui, Nahla; Jiang, Bo; Taloub, Nadia; Huang, Yu Dong

doi:10.1016/j.jconrel.2017.04.003

Cited by 80 publications

(53 citation statements)

References 310 publications

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Section: Introductionmentioning

confidence: 99%

“…Nano delivery systems, such as nanoemulsions, microcapsules, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, have many advantages in certain circumstances and are widely used. [8] So far, interests have been focused on the novel solid self-emulsification delivery system (S-SEDS). Self-emulsifying delivery systems (SEDS) is one of the most hopeful technologies in the delivery domain, particularly for the drugs with poor solubility and low bioavailability.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Solid Self‐Emulsification Delivery System for the Oral Delivery of Astaxanthin

Mao

Sun

Tian

et al. 2019

Euro J Lipid Sci & Tech

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In the present study, a solid self‐emulsification delivery system (S‐SEDS) is developed to improve the bioavailability of astaxanthin (ASX). The pseudo ternary phase diagram method is used to screen the optimum composition of liquid self‐emulsification delivery system (SEDS). This liquid system is converted into solid state using the solid absorbent carrier by simple physical mixing. Through the analysis of powder flowability and adsorption capacity, silicon dioxide and anhydrous calcium hydrogen phosphate are selected as solid carriers of the liquid self‐emulsification system. Results of Fourier transform infrared spectroscopy (FTIR) and X‐ray diffraction (XRD) indicate that astaxanthin is encapsulated in these solid carriers. In the in vitro dissolution study, sustained release of astaxanthin from two different ASX‐SEDS (prepared with silicon dioxide and anhydrous calcium hydrogen phosphate) is obtained and the cumulative release is correspondingly 51.06 ± 0.98 and 49.97 ± 0.87% within 2 h. A delayed pattern of absorbed ASX‐SEDS is observed in the study with anhydrous calcium hydrogen phosphate compared to the counterpart with silicon dioxide, which is consistent with the result from the in vitro digestion study. Antioxidant study shows that astaxanthin can be encapsulated in S‐SEDS without the loss of antioxidant activity. Consequently, S‐SEDS can be a promising vehicle in food industry. Practical Applications: Traditionally, liquid‐based delivery systems are prepared using liquid components, which have some disadvantages, such as, complex production process, low active ingredient loading, narrow application range, and lacking of effective evaluation methods. The present study adopts physical adsorption, a gentle and simple process, to prepare the solid self‐emulsifying system. This system combines the advantages of liquid‐based systems and solid dosage forms, which can improve the solubility of poorly solubility active ingredient in intestinal environments, and the high solubility of active ingredient is favor to its absorption. In the present work, the active ingredients solubilization capability of solid formulations is evaluated by in vitro dissolution and digestion studies. It can be seen that over 40% of astaxanthin are released from solid self‐emulsifying systems in 120 min. After the process of digestion, the bioaccessibility reaches 10%. The results of in vitro dissolution and digestion show that after solid adsorption, astaxanthin exhibits delayed release patterns. All the studies demonstrate that solid self‐emulsifying system is an appropriate strategy to improve the bioavailability of astaxanthin. The pseudo ternary phase diagram method is used to screen the optimum composition of liquid self‐emulsification delivery system. Then, this liquid system is converted into solid state using the solid absorbent carrier by simple physical mixing.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a Solid Self‐Emulsification Delivery System for the Oral Delivery of Astaxanthin

Mao

Sun

Tian

et al. 2019

Euro J Lipid Sci & Tech

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“…The MCMs are about 150 nm in diameter, making them suitable to deploy the EPR effect for tumor tissue uptake. In addition to a leaky vasculature leading to the EPR effect, the environment surrounding tumor tissues possess abnormal physico‐chemical properties such as decreased pH, increased temperature and unusual redox potentials . Due to the redox‐responsive nature of the peptide used to form the MCMs, the system also has a built‐in stimuli responsive delivery mechanism.…”

Section: Introductionmentioning

confidence: 99%

Delivery of ROS Generating Anthraquinones Using Reduction‐Responsive Peptide‐Based Nanoparticles

Richard

Craciun

Gaitzsch

et al. 2018

Helvetica Chimica Acta

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In order to limit the side effects associated with antitumor drugs such as doxorubicin, nanosized drug‐delivery systems capable of selectively delivering and releasing the drug in the diseased tissue are required. We describe nanoparticles (NPs), self‐assembled from a reduction responsive amphiphilic peptide, capable of entrapping high amounts of a redox active anticancer drug candidate and releasing it in presence of a reducing agent. This system shows a high entrapment efficiency with up to 15 mg drug per gram of peptide (5.8 mol‐%). Treatment of the NPs with reducing agent results in the disassembly of the NPs and release of the drug molecules. A reduction in cell viability is observed at drug concentrations above 250 nm in HEK293T and HeLa cell lines. This drug delivery system has potential for targeting tumor sites via the EPR effect while taking advantage of the increased reduction potential in tumor microenvironment.

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“…For any drug delivery system, the determination of drug and the container physiochemical properties is vital for estimation of in vivo delivery and the study of the kinetics and release behaviour [10]. A good characterization of the deigned system could lead to a good understanding to the designed system, by the way an accurate estimation of the therapeutic effect [11].…”

Section: Introductionmentioning

confidence: 99%

“…A good characterization of the deigned system could lead to a good understanding to the designed system, by the way an accurate estimation of the therapeutic effect [11]. Importantly, the drug substrate design and a precise investigation of the physiochemical properties including particle size are primordial for understanding of the possibility of DDS leakage by enhanced Plasmon Resonance effect (EPR) [12] [13], besides it capacity of drug loading in case of chemotherapy or photothermal or photodynamic effect in case of other physical therapeutic modalities [10]. The determination of particle characteristics using conventional electronic microscope of laser diffractometer with high accuracy and reproducibility was always challenging inversion problem [14], besides the nonavailability of such apparatus in every lab.…”

Section: Introductionmentioning

confidence: 99%

Particles Size Estimation of Polydopamine Based Polymeric Nanoparticles Using Near-Infrared Spectroscopy Combined with Linear Regression Method

Rahoui¹,

Hegazy²,

Jiang³

et al. 2018

AJAC

Self Cite

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The particle size is considered as a fundamental property of nanoparticles used for cargo delivery (CDS) purpose. The objective of this study was the particles size quantification of polydopamine nanoparticles (PDANS) via the near infrared spectroscopy (NIRS) combined with chemometrics tools. The successful synthesis of PDANS was proved using several characterization methods. Compared with the model extracted using raw spectral data, the accuracy and stability of the new model extracted from pre-processed data were significantly improved. The PDANS particle size samples have been predicted with acceptable accuracy. The correlation (R 2 ) between NIRS and the TEM granulometrie data was 99.81%, while the root mean square error of calibration RMSEC was 0.196 nm. This research shows that NIRS combined with a regression method is a viable tool for the quality determination of CD system.

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Spatio-temporal control strategy of drug delivery systems based nano structures

Cited by 80 publications

References 310 publications

Development of a Solid Self‐Emulsification Delivery System for the Oral Delivery of Astaxanthin

Development of a Solid Self‐Emulsification Delivery System for the Oral Delivery of Astaxanthin

Delivery of ROS Generating Anthraquinones Using Reduction‐Responsive Peptide‐Based Nanoparticles

Particles Size Estimation of Polydopamine Based Polymeric Nanoparticles Using Near-Infrared Spectroscopy Combined with Linear Regression Method

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