Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

Gaillet, Vivien; Cutrone, Annarita; Artoni, Fiorenzo; Vagni, Paola; Pratiwi, Ariastity Mega; Romero, Sandra Alejandra; Paola, Dario Lipucci Di; Micera, Silvestro; Ghezzi, Diego

doi:10.1038/s41551-019-0446-8

Cited by 60 publications

(65 citation statements)

References 64 publications

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“…In this study we exploited intraneural (TIMEs and SELINEs) electrodes, which are conceived to be transversally or obliquely inserted into the nerve, allowing spatially selective stimulation and recording from different fascicles innervating distinct peripheral targets 45,46 .Our results show that the quality of decoding performances depends on the electrode position. This could be due to the different functional role of fascicles adjacent to the recording sites and prompts the hypothesis of a specific spatial segregation of vagal fibres traversed by specific signals.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous decoding of cardiovascular and respiratory functional changes from pig intraneural vagus nerve signals

Vallone

Ottaviani

Dedola

et al. 2020

Preprint

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21Bioelectronic medicine is opening new perspectives for the treatment of some major chronic 22 diseases through the physical modulation of autonomic nervous system activity. Being the 23 main peripheral route for electrical signals between central nervous system and visceral 24 organs, the vagus nerve (VN) is one of the most promising targets. Closed-loop 25 neuromodulation would be crucial to increase effectiveness and reduce side effects, but it 26 depends on the possibility of extracting useful physiological information from VN electrical 27 activity, which is currently very limited. 28 Here, we present a new decoding algorithm properly detecting different functional changes 29 from VN signals. They were recorded using intraneural electrodes in anaesthetized pigs 30 during cardiovascular and respiratory challenges mimicking increases in arterial blood 31 pressure, tidal volume and respiratory rate. A novel decoding algorithm was developed 32 combining discrete wavelet transformation, principal component analysis, and ensemble 33 learning made of classification trees. It robustly achieved high accuracy levels in identifying 34 different functional changes and discriminating among them. We also introduced a new 35 index for the characterization of recording and decoding performance of neural interfaces. 36Finally, by combining an anatomically validated hybrid neural model and discrimination 37 analysis, we provided new evidence suggesting a functional topographical organization of 38 VN fascicles. This study represents an important step towards the comprehension of VN 39 signaling, paving the way to the development of effective closed-loop bioelectronic systems. 40 41 Algorithm, Hybrid Modeling Framework. 44 45 46 48 of body homeostasis. In ANS peripheral nerves, afferent and efferent fibres run together, 49 providing bidirectional communication between specific circuits of the central nervous 50 system and visceral organs. The artificial modulation of this complex circuitry is the 51 challenging goal of bioelectronic medicine (BM), a highly promising alternative to some 52 limited pharmacological tretments 1-3 . Among the main ANS nerves, the vagus nerve (VN) 53 represents a privileged target as it modulates vital functions like respiration, circulation and 54 the digestion 4 . VN stimulation (VNS) of cervical segments has shown a great potential for 55 the treatment of a wide range of pathological conditions such as epilepsy 5 , chronic heart 56 failure 6 , and inflammatory diseases 7,8 . However, the formidable amount of afferent and 57 efferent signals that simultaneously cross this VN segment, the numerous VNS side-effects 9 58 and the discovery of VN involvement in the regulation of complex functions like immunity 10 59 or central neuroplasticity 11,12 highlight the need for high precision and selectivity. In an ideal 60 scenario, the therapeutic stimulation or inhibition of VN or any other ANS nerve should be: 61 a) selectively directed to specific efferent or afferent fibres and b) regulated by a ...

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Section: Discussionmentioning

confidence: 99%

Simultaneous decoding of cardiovascular and respiratory functional changes from pig intraneural vagus nerve signals

Vallone

Ottaviani

Dedola

et al. 2020

Preprint

Self Cite

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“…Animal experiments were approved by the Département de l'emploi, des affaires sociales et de la santé (DEAS), Direction générale de la santé of the Republique et Canton de Genève (Switzerland, authorization GE1416). The procedure was previously described . Female New Zealand White rabbits (>16 weeks, >2 kg) were sedated with an intramuscular injection of xylazine (5 mg kg −1 ).…”

Section: Methodsmentioning

confidence: 99%

“…The procedure was previously described. [18] Female New Zealand White rabbits (>16 weeks, >2 kg) were sedated with an intramuscular injection of xylazine (5 mg kg À1 ). Anesthesia and analgesia were provided with an intramuscular injection of an anesthetic mix composed of medetomidine (0.5 mg kg À1 ), ketamine (25 mg kg À1 ), and buprenorphine (0.03 mg kg À1 ).…”

Section: Methodsmentioning

confidence: 99%

All‐Printed Electrocorticography Array for In Vivo Neural Recordings

Borda

Ferlauto

Schleuniger³

et al. 2020

Adv Eng Mater

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Bioelectronic and neuroprosthetic interfaces rely on implanted microelectrode arrays (MEAs) to interact with the human body. Printing techniques, such as inkjet and screen printing, are attractive methods for the manufacturing of MEAs because they allow flexible, room‐temperature, scalable, and cost‐effective fabrication processes. Herein, the fabrication of all‐printed electrocorticography arrays made by inkjet printing of platinum and screen printing of polyimide is shown. Next, mechanical and electrochemical characterizations are performed. As a proof of concept, in vivo visually evoked cortical potentials are recorded in rabbits upon flash stimulation. Lastly, it is shown that the all‐printed electrocorticography arrays are not cytotoxic. Altogether, the results enable the use of printed MEAs for neurological applications.

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“…In an effort to enhance fiber selectivity, penetrating electrode arrays have been inserted into the optic nerve. These MEAs can elicit cortical responses in animal models Li et al, 2008;Lu et al, 2013;Gaillet et al, 2019) and one penetrating array, with wire electrodes progressing through the optic disk and into the optic nerve, has been implanted in a human patient (Sakaguchi et al, 2009). Similar to retinal prostheses, optic nerve prostheses, both surfacebased and penetrating, benefit from a relatively less invasive intraocular surgery.…”

Section: Optic Nervementioning

confidence: 99%