Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient

Chen, X. J.; Möller, Harald E.; Chawla, Mark S.; Cofer, Gary P.; Driehuys, Bastiaan; Hedlund, Laurence W.; Johnson, G. Allan

doi:10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d

Cited by 173 publications

(188 citation statements)

References 22 publications

(25 reference statements)

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“…The free diffusion of 129 Xe is 0.14 cm 2 · s −1 31; in this study, we report 0.22 cm 2 · s −1 for 129 Xe in the trachea. The higher ADC value for 129 Xe in the trachea, we presume is due to its mixture with the highly diffusive 3 He (as shown in Table 1).…”

Section: Discussionsupporting

confidence: 42%

RF instrumentation for same‐breath triple nuclear lung MR imaging of ¹H and hyperpolarized ³He and ¹²⁹Xe at 1.5T

Rao

Wild

2015

Magnetic Resonance in Med

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PurposeThe hyperpolarized gases 3He and 129Xe have distinct properties and provide unique and complementary functional information from the lungs. A triple‐nuclear, same‐breath imaging examination of the lungs with 1H, 3He, and 129Xe can therefore provide exclusive functional information from the gas images. In addition, the 1H images provide complementary co‐registered structural information in the same physiological time frame. The goal of this study was to design an RF system for triple nuclear lung MRI at 1.5T, consisting of a dual‐tuned transceiver coil for 3He and 129Xe, RF switches and a nested 1H receiver array.MethodsA dual‐tuned transmit‐receive dual‐Helmholtz RF coil for 3He and 129Xe was designed and constructed to work in unison with a nested 1H receiver array.ResultsTriple‐nuclear imaging (structural and ventilation) and apparent diffusion coefficient mapping of the human lungs was performed in the same breath‐hold using the integrated RF system. B1 maps and volumetric ventilation imaging using a three‐dimensional, balanced steady‐state free precession pulse sequence performed with both hyperpolarized 3He and 129Xe indicate good stand‐alone performance of the coil for the respective nucleus.ConclusionTriple‐nuclear same‐breath lung imaging with a dual‐tuned coil (3He and 129Xe) and a nested 1H array has been demonstrated with a custom RF system. Magn Reson Med 75:1841–1848, 2016. © © The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

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Section: Discussionsupporting

confidence: 42%

RF instrumentation for same‐breath triple nuclear lung MR imaging of ¹H and hyperpolarized ³He and ¹²⁹Xe at 1.5T

Rao

Wild

2015

Magnetic Resonance in Med

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“…Similar measures, combined with quantitative measures of airway lumen size and wall thickness, may also allow measurement of gas trapping and airway narrowing associated with other obstructive lung diseases such as asthma (24). Although HR CT can provide quantitative assessment and diagnosis of the anatomical features of lung diseases, HP MRI has the means to perform a range of functional measures including regional ventilation (25)(26)(27), and V A /Q mapping (28,29), while also providing images of regional microstructure-in some applications at length scales similar to or smaller than those depicted on CT (30,31)-and all of these measures are performed without ionizing radiation.…”

Section: Lung Imaging Techniquesmentioning

confidence: 99%

“…Sequences with longer readout times, likely to find application in lower field scanners (47), will benefit from the lower diffusion coefficient of Xe-129 compared to He-3. Also, the lower diffusion coefficient of Xe can be exploited for diffusion-weighted (DW) imaging applications designed to more readily measure alveolar and small airway dimensions (50 -300 m) (30).…”

Section: Hyperpolarized Gas Agentsmentioning

confidence: 99%

Functional lung imaging using hyperpolarized gas MRI

Fain

Korosec

Holmes

et al. 2007

Magnetic Resonance Imaging

177

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The noninvasive assessment of lung function using imaging is increasingly of interest for the study of lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma. Hyperpolarized gas MRI (HP MRI) has demonstrated the ability to detect changes in ventilation, perfusion, and lung microstructure that appear to be associated with both normal lung development and disease progression. The physical characteristics of HP gases and their application to MRI are presented with an emphasis on current applications. Clinical investigations using HP MRI to study asthma, COPD, cystic fibrosis, pediatric chronic lung disease, and lung transplant are reviewed. Recent advances in polarization, pulse sequence development for imaging with Xe-129, and prototype low magnetic field systems dedicated to lung imaging are highlighted as areas of future development for this rapidly evolving technology.

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“…HYPERPOLARIZED 3 HE GAS (HHe) is an inhaled contrast agent that provides detailed information about lung function and structure in MRI (1)(2)(3)(4). Because no ionizing radiation is used in MRI and 3 He is a biologically inert gas, HHe MRI is a very safe imaging technique.…”

mentioning

confidence: 99%

q‐space analysis of lung morphometry in vivo with hyperpolarized³He spectroscopy

Shanbhag

Altes

Miller

et al. 2006

Magnetic Resonance Imaging

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Purpose:To examine the utility of a 3 He spectroscopic q-space technique for detecting changes in lung morphometry in vivo. Materials and Methods:A diffusion-weighted spectroscopy sequence was used to collect global diffusion data from healthy adults (N ϭ 11), healthy children (N ϭ 5), and chronic obstructive pulmonary disease (COPD) patients (N ϭ 2) using 40 cc of hyperpolarized 3 He gas within a two second breathhold. Displacement probability profiles (DPP) were obtained by Fourier transformation of diffusion data with respect to q. A bi-Gaussian model was used to decompose the DPPs into narrow and broad components, characterized by root-mean-square displacements X rms1 and X rms2 , respectively. Results:In healthy adults, the narrow component (X rms,1 ) of the DPP had a mean displacement of 188 Ϯ 10 m, slightly less than the reported average size of the alveoli. The broad component (X rms,2 ) had a mean value of 474 Ϯ 44 m, comparable to the diameter of the respiratory bronchioles in the acinus. In children, both X rms1 (167 Ϯ 4 m) and X rms2 (382 Ϯ 22 m) compared to healthy adults (P Ͻ 0.01). In COPD patients, the mean displacements were elevated (X rms1 : 265 Ϯ 71 m; X rms2 : 530 Ϯ 109 m) compared to healthy adults. Excellent correlation was found between rms displacements and age (age vs. X rms,1 : r ϭ 0.78, P Ͻ 0.001; age vs. X rms,2 : r ϭ 0.90, P Ͻ 0.001). Conclusion:The q-space parameters agreed remarkably well with published alveolar morphometry data. The results suggest that the technique may be sensitive to disease, as evident from the elevated mean displacements in COPD patients compared to healthy volunteers. Detailed lung microstructural information can be obtained using a very low volume of inhaled 3 He.

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Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient

Cited by 173 publications

References 22 publications

RF instrumentation for same‐breath triple nuclear lung MR imaging of ¹H and hyperpolarized ³He and ¹²⁹Xe at 1.5T

RF instrumentation for same‐breath triple nuclear lung MR imaging of ¹H and hyperpolarized ³He and ¹²⁹Xe at 1.5T

Functional lung imaging using hyperpolarized gas MRI

q‐space analysis of lung morphometry in vivo with hyperpolarized³He spectroscopy

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Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient

Cited by 173 publications

References 22 publications

RF instrumentation for same‐breath triple nuclear lung MR imaging of 1H and hyperpolarized 3He and 129Xe at 1.5T

RF instrumentation for same‐breath triple nuclear lung MR imaging of 1H and hyperpolarized 3He and 129Xe at 1.5T

Functional lung imaging using hyperpolarized gas MRI

q‐space analysis of lung morphometry in vivo with hyperpolarized3He spectroscopy

Contact Info

Product

Resources

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RF instrumentation for same‐breath triple nuclear lung MR imaging of ¹H and hyperpolarized ³He and ¹²⁹Xe at 1.5T

RF instrumentation for same‐breath triple nuclear lung MR imaging of ¹H and hyperpolarized ³He and ¹²⁹Xe at 1.5T

q‐space analysis of lung morphometry in vivo with hyperpolarized³He spectroscopy